Homo-and copolymers of 2-(N-phthalimido)ethyl methacrylate (NPEMA) and p-chlorophenyl methacrylate (PCPMA) were prepared in N,N-dimethyl formamide (DMF) solution at 70 °C using 2,2-azo-bisisobutyronitrile (AIBN) as initiator. The nano-CdS-doped polymer composite of NPEMA and PCPMA was prepared via in situ technique. The homo-and copolymers of NPEMA and PCPMA were characterized using FT-IR spectroscopy and gel permeation chromatography (GPC). The polymer nano composites were characterized using FT-IR spectroscopy, X-ray diffraction, and transmission electron microscopy. The reactivity ratios (r 1 and r 2 ) were obtained from the various linear graphical methods. The values of r 1 (NPEMA) = 0.55 and r 2 (PCPMA) = 1.30 were found from the same graphical methods. The copolymer microstructures were found from the mean sequence length, run number, and dyad fraction. Thermal behavior of polymers and polymer nano composites under nitrogen atmosphere was studied. The activation energies of neat polymers were varied in the range of 56-85 kJ/mol, while 28-56 kJ/mol energies were found for nano-CdS-doped polymer composites. The thermodynamic parameters of thermal degradation were also obtained. Kinetic and thermodynamic parameters were confirming the stability of the neat polymers than polymer nano composites. The polymers were assessed on different microorganisms for obtaining the antimicrobial properties. Overall, the polymers permit 10-52, 20-58, and 18-56% growth of bacteria, fungi, and yeast, respectively.
A novel Schiff base [SAL-L=2-((2,3-dihydro-1H-inden-4-ylimino)methyl phenol] was synthesized and used as ligand for the synthesis of Ni(II) and Co(II) complexes. The structural characterization of ligand and its Ni(II) and Co(II) complexes was determined using various spectroscopic methods. Based on spectral studies, a square planar and octahedral geometry have been proposed for Ni(II) and Co(II) complexes, respectively. DNA binding properties of these metal complexes with calf-thymus DNA in tris-hydrochloride buffer (pH 7.2) were investigated using UV- visible absorption studies. The binding constants were in the order of 105 M-1 suggested a good binding affinity towards CT-DNA.
The synthesized ligand is docked on TSPO protein showing good binding energy and found to be a potent inhibitor of cancer.
Novel Schiff base was synthesized from 1:1condensation of thiophene 2-carboxaldehyde and 4-Amino indane. Two solid transition metal complexes (Ni and Co) were synthesized with this ligand. The structure of ligand (2-THIO-L) and its complexes are confirmed by various spectral characterization methods. 2-THIO-L and its metal complexes are tested for antibacterial activity against Staphylococcus aureus and Escherichia coli. Both show more activity against Gram+ve than Gram-ve bacteria. Molecular docking studies of ligand (2-THIO-L) against MAP2K6 indicated that they are potential inhibitors of carcinogenic receptors. DNA binding interactions of the nickel and cobalt complexes with CT-DNA in tris hydrochloride buffer at pH-7.2 are investigated using UV-Visible spectroscopy. The binding constants are in the range of 10 5 M -1 showed hypochromism which indicate good binding affinity towards CT-DNA.
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