Introduction Many studies have been done comparing sutures versus skin staples in various wounds. To the author's knowledge, there is no study comparing these two in an laparoscopic cholecystectomy (LC) wound. Our study aims at comparing the clinical outcome of skin closure by monofilament nylon suture and stainlesssteel skin stapler in standard four-port LC. The results of this study can help in developing guidelines for skin closure in LC. Objective To compare the clinical outcome of skin closure by monofilament nylon suture and stainless-steel skin stapler in standard four-port LC. Methods The study was conducted as a time-bound prospective cohort study on diagnosed patients of cholelithiasis admitted in a single unit of the
Background: Abnormal uterine bleeding (AUB) is the commonest presenting symptom in gynaecology out- patient department. Endometrial sampling could be effectively used as the first diagnostic step in AUB. This study was done to evaluate histopathology of endometrium for identifying the endometrial causes of AUB. And also, to observe the incidence of various endometrial pathology in different age groups presenting with abnormal uterine bleeding.Methods: A one-year prospective study conducted in the department of obstetrics and gynaecologist in A. J. institute of medical sciences and research centre which included 200 cases of clinically diagnosed AUB patients. Histopathological examination of endometrial biopsies specimens was done, followed by clinical correlation.Results: The most common age group presenting with AUB was 41-50 years (43.84%). The commonest pattern in these patients was normal cycling endometrium (42.32%). The commonest pathology irrespective of the age group was disordered proliferative pattern (26.15%). Other causes identified atrophic endometrium (11.5%), benign endometrial polyp (5.38%), endometrial hyperplasia (5.41%), carcinomas (0.79%) and chronic endometritis (1.54%).Conclusions: The knowledge of endometrial pattern in a case of AUB helps to decide a plan of management. Endometrial sampling plays a very important role in management of AUB, especially in the age group of more than 40 years; i.e., the peri and post-menopausal age groups, where incidence of malignant or pre malignant conditions was noted to be the highest.
Introduction: Gall bladder cancer is one of the most common malignancy of biliary tract. Incidence of this disease is high in Indo-Gangetic Belt of India (Central and Northern India). The study was carried out in Hepato-Pancreato-biliary Unit of Surgery Department of AIIMS Rishikesh, India, tertiary institution located in the same region. Aim of the study was to find an alternate tumor marker which was cheaper, specific and help in prognosticating the patients who have developed this dreadful disease. Platelet distribution width (PDW) is a tumor marker which has been associated with lot of malignancies like colorectal malignancies, papillary carcinoma of thyroid, melanoma patients and have been found to have increased values compared to a control group Method: Measurement of PDW was done using SYSMEX automated blood analyzer. Reference range for platelet distribution width was found to 9.30-14.30fl in males and 9.80-16.00fl in females with average value being 12.35. Data analysis was done using SPSS v24.0. Result: On studying 100 patients with carcinoma of gall bladder, the mean value of PDW obtained in patients suffering from carcinoma of gall bladder was found to 16.55 (increased level compared to normal population). PDW was found to have correlation of 26% with CA-19.9 , 6.5% with CEA and 2.2% with CA-125 Conclusion: Various theories have been suggested for the raised level of PDW; is was suggested to be due to increase in platelet growth factor production causing increased anisopoikilocytosis leading to raised platelet distribution width. This was a pilot study done to identify the association of PDW with Carcinoma of gall bladder and has found a positive correlation with the index.This study is able to demonstrate that PDW can be used as a surrogate biomarker for patients of GB Carcinoma.
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