safety. When comparing the direct anticoagulant dabigatran with warfarin no difference in stroke prevention at higher TTR was shown. (3) TTR greater than 70% conferred better survival for patients with moderate or high-risk patients. (4) In patients with AF, the quality of anticoagulation is stratified according to the percentage TTR where less than 50% is considered bad quality, more than 60% being satisfactory and more than 70% conferring optimal anticoagulation. The report from a post-hoc analysis of the Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascular Events (ACTIVE-W) indicated that if
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