In the present investigation comparison of three different superdisintegrants was carried out by formulating orally disintegrating tablets. Promethazine HCl was used as model drug which is an antiemetic drug. Sodium starch glycolate, croscarmellose and crospovidone were selected as superdisintegrants and each one was used in three different concentrations (2%, 3.5% and 5%). The drug-polymer compatibility was ruled out by FTIR studies. A total of nine formulations (PF1-PF9) were made by direct compression. All prepared formulations were evaluated for weight variation, hardness, friability, drug content, disintegration time, wetting time and in vitro drug release parameters. The results of the evaluation parameters for all the nine formulations of promethazine HCl were within the standard limits. The in vitro drug release for promethazine HCl tablets of all the formulations (PF1-PF9) was carried out using phosphate buffer pH 6.8 as dissolution medium. Among all the formulations the tablets formulated with crospovidone (PF7-PF9) have shown 91.43 - 98.43% (maximum) drug release at the end of 10 min than sodium starch glycolate and croscarmellose, hence from the present work, it concluded that among three superdisintegrants crospovidone is the ideal superdisintegrant for formulating oral disintegrating tablets for promethazine HCl.
Aim: The present research work was aimed to develop a novel emulgel for aceclofenac to enhance the drug absorption by the topical application, which overcomes the demerits of oral dosage form and conventional gel system of aceclofenac. Materials and Methods: The emulgels were prepared with carbopol 934 as a gelling agent used in six different concentrations. Span 20 and Tween 20 were included as emulsifying agents in two different concentrations. Liquid paraffin was used as an oil phase, and methyl and propylparaben were included as preservatives. Ethanol was used to dissolve the drug for preparing the aqueous phase and Triethanolamine was added at the end of preparation, as quantity sufficient for pH adjustment. Results: All the formulated emulgels were screened for the parameters, namely, appearance, pH, rheology study, spreadability, swelling index, drug content, and in vitro drug release studies. The optimized formulation AG-4 showed 91.43% of drug release with sustained-release manner up to 6 h, and the particle size analysis reported good size range, and the emulgel was found to be nonirritant and nontoxic which was confirmed by HET CAM test. Conclusion: Aceclofenac can be successfully formulated as emulgel for better-sustained effect and can be a suitable alternative approach to the oral dosage forms for the management of arthritis.
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