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MANY of the members will remember the interest that was taken in the fossils which were exposed in the excavation of the Dry Dock of Garvel Park, Greenock, eleven years ago, and the lively discussions at the meetings of the Society from time to time, regarding the various sections as they were laid open. The recent commencement of the excavation for the Wet Dock at the same place gave hopes of a renewal of the same interest, which have not been disappointed. Although the much greater extent of cutting has brought clearly into view the normal sequence of the beds, leaving little or nothing for difference of opinion on that point, yet the interest has been well sustained by the unusual variety and distribution of the fossil remains. During the excavation of the Dry Dock our workers were mostly, if not all, from Glasgow. This time there has been a strong accession from Greenock, amongst them Messrs. J. and T. Steel, and prominently Mr. Thomas Scott, whose untiring industry has been rewarded with many of the fortunate finds of the place. In preparing the lists of fossils my thanks are due for assistance in the identification of doubtful and critical species; to Dr. Gwyn Jeffreys, for Mollusca; to Mr. H. B. Brady, for Foraminifera; to the Rev. A. M. Norman, for Polyzoa; to the Rev. R. T. Ferguson, for Mosses; to Professor Dickie, for Algse; and to Professor Bay ley Balfour for Vascular Plants; the lists through their help having received a value, as stated on other occasions, that they could not otherwise possess. VOL. VII. A California-San Diego on June 8, 2015 at University of http://trngl.lyellcollection.org/ Downloaded from 2 TRANSACTIONS OF THK GEOLOGICAL SOC. OF GLASGOW.Boulder clay.-It is beyond the scope of this paper to enter into the many theories adduced to explain the mode of deposition of the Boulder-clay, and I shall therefore confine my remarks, with fewexceptions, to that met with in the section at Garvel Park. It is similar to what we find all over the West of Scotland, which has been so often described as a stiff unstratified clay, more or less crowded with stones varying in size from small gravel up to blocks of several tons weight. There may be generally about 50 per cent, of these stones water-worn, and some kinds more fre quently showing striation than others, owing, apparently, to the composition and greater or less compactness of the stone. Perhaps the best preserved striations are found on limestone and hard shale. The following is a list of the contents of a small parcel of Boulder-clay from the south end of the dock, 14 feet under the surface, excluding stones over 1£ ounces in weight:-Fine Mud, ... 68 per cent. Sand, all angular, chiefly quartz, ... 15 ,, Small gravel, J quartz, J dark coloured, ... 6 ,, Larger gravel, \ quartz, f schists, 11 ,,In a collection of larger carried stones as the size increases so does the proportion of dark schistose rocks, the smaller portions of which have apparently been ground and triturated into an impal pable powder forming the great proportion of fine mu...

We examined the properties of several enzymes of phospholipid metabolism in axoplasm extruded from squid giant axons. The following synthetic enzymes, CDP-diglyceride: inositol transferase (EC 2.7.8.11), ATP:diglyceride phosphotransferase, diglyceride kinase (EC 2.7.2.-), and phosphatidylinositol kinase (EC 2.7.1.67), were all present in axoplasm. Phospholipid exchange proteins, which catalyzed the transfer of phosphatidylinositol and phosphatidylcholine between membrane preparations and unilamellar lipid vesicles, were also found. However, we did not find conditions under which the synthesis of CDP-diglyceride, phosphatidylserine, and phosphatidylinositol-4,5-diphosphate could be measured. Subcellular fractionation by differential centrifugation showed that the axoplasmic inositol transferase and phosphatidylinositol kinase activities were largely "microsomal," while the diglyceride kinase and exchange protein activities were primarily "cytosolic."

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Response-adaptive randomization (RAR) is part of a wider class of data-dependent sampling algorithms, for which clinical trials have commonly been used as a motivating application. In that context, patient allocation to treatments is defined using the accrued data on responses to alter randomization probabilities, in order to achieve different experimental goals. RAR has received abundant theoretical attention from the biostatistical literature since the 1930's and has been the subject of heated debates. Recently it has received renewed consideration from the applied community due to successful practical examples and its widespread use in machine learning. Many position papers on the subject present a one-sided view on its use, which is of limited value for the non-expert. This work aims to address this persistent gap by providing a critical, balanced and updated review of methodological and practical issues to consider when debating the use of RAR in clinical trials.

Modern biomedical research frequently involves testing multiple related hypotheses, while maintaining control over a suitable error rate. In many applications the false discovery rate (FDR), which is the expected proportion of false positives among the rejected hypotheses, has become the standard error criterion. Procedures that control the FDR, such as the well-known Benjamini-Hochberg procedure, assume that all p-values are available to be tested at a single time point. However, this ignores the sequential nature of many biomedical experiments, where a sequence of hypotheses is tested without having access to future p-values or even the number of hypotheses. Recently, the first procedures that control the FDR in this online manner have been proposed by Javanmard

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