BACKGROUND: The global scale of the pandemic of a new coronavirus infection is determined by the involvement of the entire world population in the problem. Recently, the scientific and medical community has been paying increased attention to the consequences of COVID-19, including aspects of the rehabilitation of patients who have had this infection. AIM: to evaluate the effectiveness and safety of including ozone therapy in the rehabilitation of patients with long COVID. MATERIALS AND METHODS: This randomized controlled clinical trial included 51 patients aged 29 to 78 years with a confirmed diagnosis of pneumonia associated with SARS-CoV-2 (J12.8). Patients were divided into three statistically comparable groups depending on the complex of rehabilitation treatment, which they received. In the first (control) group (n=17), a 10-day course included daily breathing exercises and physiotherapy for the lungs. In the second (main) group (n=18), in addition to the complex of basic measures, daily intravenous infusions of ozonized saline with an ozone concentration of 2.0 mg/l were performed daily. Patients in the third group (comparison, n=16) received ozone therapy every other day. In order to determine the effectiveness and safety of the inclusion of systemic ozone therapy in a comprehensive program for the rehabilitation of patients after COVID-19, an analysis of blood oxygen saturation in air, laboratory parameters (D-dimer and C-reactive protein), changes in peripheral blood flow, a decrease in patients' oxygen demand to and after a 10-day course of rehabilitation treatment. The dynamics of patients' complaints and changes in the patient's quality of life during rehabilitation were assessed using the EQ5D questionnaire. RESULTS: All patients during rehabilitation had positive dynamics in all parameters, there were no adverse reactions during the course and 2 months after rehabilitation. An analysis of various indicators revealed a greater effectiveness in prescribing systemic ozone therapy for rehabilitation. When comparing different methods, it turned out that daily ozone therapy had a better effect on laboratory parameters than daily ozone therapy. CONCLUSIONS: The use of ozone therapy in the complex rehabilitation of patients after COVID-19 is safe and effective. Further study in more patients is needed to determine indications and criteria for use.
Background: Early rehabilitation is an important strategy for the treatment of severe diseases. The study aimed to assess the efficacy of early rehabilitation of patients with mild-to-moderate COVID-19. Methods: The retrospective single-center study with propensity score matching. Results: 180 patients (54 (44 - 62.3) yo) divided into three equal groups: 1 - physical exercises; 2 - physical exercises and chest massage in an electrostatic field; 3 - no rehabilitation. The length of stay (LOS) in the hospital in group 1 was 14 (11-15) days, group 2 - 13 (11-15) days, group 3 - 15 (13-18) days, p=0.0026. Physical exercises for patients with CT-1 improved the quality of life, assessed by the EQ-5D questionnaire, by reducing the level of anxiety and depression. The Hazard Ratio (HR) for desaturation (<93%) was 2.34 (95% Confidence Interval (CI) 1.18-4.63) for group 2, p=0.001. The HR for C-reactive protein level above 50 mg/l in patients with CT-2 was 2.33 (95% CI 1.56-3.47), p=0.0001. Conclusions: Rehabilitation programs are safe for СOVID-19-patients; reduce hospital LOS; improve the quality of life. Continuous monitoring of a patient's condition during rehabilitation is essential. ClinicalTrials.gov ID: NCT0580836
Purpose of the study. To assess the impact of systemic ozone therapy on the emotional state of patients after the novel coronavirus infection in the early recovery period. Materials and methods. A randomized controlled clinical trial, including 39 patients aged 29 to 78 years with a confirmed diagnosis of bilateral polysegmental viral pneumonia associated with SARS-CoV-2 coronavirus (J12.8), was conducted. The patients were divided into 2 statistically comparable groups. In the first group (N=19), the patients received a standard complex of rehabilitation treatment: exercise therapy, chest massage, and physiotherapy procedures (low-frequency magnetic therapy and drug electrophoresis in the projection of the lung fields), while the patients in the second group received daily intravenous infusions of ozonated saline solution with an output ozone concentration of 2.0 mg/l in addition to the basic complex rehabilitation. In order to assess the impact of systemic ozone therapy on the emotional state of the patients who underwent COVID-19, we analyzed the dynamics of complaints, changes in the quality of life of the patient based on the EQ-5D-3L questionnaire, as well as the severity of anxiety and depression according to the results of the HADS (Hospital Anxiety and Depression Scale) on the 1st and 10th days of the rehabilitation treatment. Results. In all patients, positive dynamics was noted against the background of rehabilitation measures in relation to complaints, the severity of anxiety and depression, as well as the quality of life. At the same time, the analysis of various indicators revealed greater efficiency in the prescription of a comprehensive program, including systemic ozone therapy. Conclusions. The use of ozone therapy in the complex rehabilitation of patients who have undergone COVID-19 has shown its efficiency and safety. Further study in higher number of patients is required to determine indications and criteria for its use.
Aim of the study. To study the safety and efficacy of hypoxic-hyperoxic treatment in the complex of rehabilitation measures in patients after COVID-19 associated pneumonia. Materials and methods. The study included 20 patients aged 49 to 75 years after viral pneumonia caused by the novel coronavirus infection (ICD-10 U07.1 and U07.2). The patients were divided into two groups according to the rehabilitation treatment received. In the first group (n = 10), the rehabilitation treatment was carried out in the scope of therapeutic exercises, massage and physiotherapy procedures. In the second group (n = 10), procedures for hypoxic-hyperoxic treatment were added to the complex of basic measures. Results. Our experience in conducting a rehabilitation course and including hypoxic-hyperoxic treatment in complex rehabilitation programs for patients in the early recovery period after viral pneumonia associated with the novel coronavirus infection revealed positive dynamics in terms of increasing Conclusions. exercise tolerance, reducing anxiety and depression, and improving the quality of patients’ lives. The use of hypoxic-hyperoxic treatment as part of a general rehabilitation course has shown its safety and efficacy for patients who had pneumonia associated with the novel coronavirus infection.
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