Background: The emerging role of precision medicine among in oncologic science is a potentially explorable area to solve long-standing implication of triple-negative breast cancer (TNBC)’s management, especially by identifying programmed cell death ligand-1 (PD-L1) in its population. Objective: To describe the PD-L1‘s expression among TNBC populations in our Indonesia-based centers. Methods: This descriptive study was conducted in the teaching hospitals of Universitas Sumatera Utara ranging from April 2019 to July 2020. Our investigation encompassed female individuals with histopathologically confirmed TNBC and complete medical record data, especially the status of PD-L1 expression to be reported in this study. We use Daco 22C3 antibodies to confirm the latter protein immunohistochemical positivity after thorough specimen preparation and staining. Results: This study included 60 females with TNBC of which 40 participants were issued in the final report. Our populations were dominated by middle-aged individuals (41-50 years old; 45%), and remarkable presentation of LVSI, angioinvasion, or lymph-node metastatic status. In PD-L1 expression status, our study reported that 45.0% patients were confirmed with confirmed PD-L1 positivity. Conclusion: PD-L1 expression among TNBC patients is concordant with the global report hence anti-PD-1-based treatment trial in Asia or even Indonesia region should be considered.
Indonesia is one country that is known for its natural wealth. Various types of flora and fauna living in this country. Examples of rich fauna that exist in Indonesia and can still be found at this point that one-horned rhino (Java rhinoceros), Sumatran elephant, Sumatran tiger, deer Bawean even dragons. However, over the times that make more and more people are not responsible for expanding residential land for private purposes and poaching that occurred in Indonesia, the animals are increasingly difficult to find because of habitats and their populations are dwindling. In this research, researchers applied a mixed reality technology with voice input to bring the Indonesian endangered species that has begun difficult to be found with the actual scale without having to disturb the habitat or environment. How it works is a mixed reality which brings together the virtual world with the real world. So that thanks to the development of today’s technological world, users can feel the direct presence of these animals without having to hunt or look for them.
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