The current work focused on the synthesis of novel chromone biheterocycle analogs followed by its characterization through physico-chemical and spectral techniques like FTIR, mass and NMR spectroscopy. The basic triazole heterocycle and its analogs have different biological properties. At the point when one biological active molecule is connected to another, the resultant shows improved potency (biheterocycles). Chromone and triazole are selected in this study to develop new efficient, simple, economically viable and biologically active synthetic compounds. All the novel derivatives of triazole linked chromone biheterocycles were synthesized via a click chemistry procedure and screened for in vitro antimicrobial, antifungal and antioxidant studies. Among them, the compounds CRN-F (IC50 = 35.97), CRN-H (IC50 = 28.76) and CRN-J (IC50 = 29.72) have significant free radical scavenging activity in comparison with the ascorbic acid as control standard (IC50 = 23.07). Some of these novel derivatives exhibited moderate antimicrobial and antifungal activity compared to that of the reference standards. Hence, the novel chromone biheterocycle analogs played a protective role against oxidative damage.
Dengue is an acute viral infection in tropical and subtropical regions. Dengue is a major public health difficulty in numerous regions of the world. Demographic features of dengue fever have changed tremendously in India. The aim of the study is to explore the epidemiological and clinical features of dengue fever. During the study period, positive cases were reported in the months of September to February. In our study population, of the 57-dengue patient's majority were males with 59.64% and females were 40.35%. Maximum infected age group was 26 to 30 years with 18 (31.57%) and minimum was 6-10 years with 1 (1.75%) patient. Fever was present in almost all the cases followed by headache, Myalgia, Arthralgia, vomiting and diarrhea, body pain, nausea, abdominal pain, skin rash and giddiness. Hyperthermia, tachycardia, tachypnea was also noticed. Dehydration (8.77%), Epigastric tenderness (7.01%), toxic tongue coat (7.01%) and Icterus (10.52%) were present in patients. High blood sugar levels (10.52%), slightly turbid urine (8.77%), leukopenia (47.36 %), and thrombocytopenia (91.22 %), neutropenia (22.80%), and lymphocytopenia (47.36 %), monocytopenia (8.77%), Leukocytosis (12.28 %), Neutrophilia (26.31%), Lymphocytosis (31.57%), and Eosinophilia (29.82%) were found. Dengue virus is currently a problematic global infection and clinical and laboratory features of dengue cases studied could be used for the early identification of patients at risk of severe dengue fever.
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