The characteristics of the disease are given, the urgency of the problem is emphasized. The degree of infestation of fish with botryocephalus during the growing season and the effectiveness of therapeutic and preventive treatments by helminthological opening of 40-50 fish from the pontoon line before using the preparation; and of 40-50 fish on the 4th or 5th day after the therapeutic feeding are established. An assessment of various methods and frequency of application of therapeutic feed with microsalum is given, as well as recommendations on the use of therapeutic feed both for preventive and therapeutic purposes are given.
Всероссийский научно-исследовательский институт фундаментальной и прикладной паразитологии животных и растений -филиал Федерального государственного бюджетного научного учреждения «Федеральный научный центр -Всероссийский научно-исследовательский институт экспериментальной ветеринарии имени К. И. Скрябина и Я. Р. Коваленко Российской академии наук»,
Bothriocephalosis of fish is a disease caused by tape worms Bothriocephalusopsariichthydis and Bothriocephalus acheilognathi parasitizing in the anterior partof intestine. Bothriocephalus spp. infection is widely spread among fish at pondfarms, cage fish farms in cooling ponds of thermal power and nuclear powerstations and in natural reservoirs. One have revealed Bothriocephalus in 26 speciesof fish attributed to Cyprinidae family, in salmons (Arctic salmon) and in somepredatory fish (catfish, pikeperch). Different species of cyclopes serve as theintermediate hosts necessary for development of helminths. Fish fry and fingerlingsare the most susceptible ones to infection. Fish of older age groups are lesssusceptible to this parasite. The data on biology, epizootology, clinical features andpathogenesis, diagnostics, therapeutic and prophylactic measures against thisinfection are represented. The results of the field trials with microsal againstBothriocephalosis in carps and grass carps carried out in different regions of theRussian Federation as well as monitoring of the safe use of microsal for the studyperiod (2007 to 2016) are described. The daily dose of medicated feed with 2% ofmicrosal corresponds to the daily feeding for fish. The therapeutic feeding iscarried out during one day without preliminary starvation period according to thecurrent technology of fish feeding with granulated feed. The dose level accordingto the active substance depends on water temperature and average fish weight andranges 12 to 40 mg/kg. Prophylactic treatment is carried out twice a year: in lateApril – early May and in late August – early September (at pond farms) and in lateSeptember – early October (at cage fish farms) when the water temperature is nothigher 150 C. In general the data obtained for 10 year period evidence aboutmicrosal’s safety for fish and at it's current application (according to theinstructions) the reasonable benefit/risk ratio is maintained in all cases.
The purpose of the research is to develop and test new combined dosage forms against bothriocephalosis of cyprinids in the cage culture fishery.Materials and methods. Combined micronized Niclosamide- and Albendazole-based dosage forms were developed; labscale batches of dosage forms of drugs and medicated feeds were developed with these drug forms; Bothriocephalus sp. infection rate in fish was determined during the growing period; and preliminary test effectiveness was confirmed for combined micronized niclosamide- and albendazole-based dosage forms against bothriocephalosis in cyprinids in the incubation shop of a cage culture fishery according to standard practices. The efficacy was assessed for combined micronized niclosamide- and albendazole-based dosage forms.Results and discussion. The preliminary tests of combined micronized Albendazole- and Niclosamide-based dosage forms as part of medicated feeds showed 100% extense-effectiveness with 100% intense-effectiveness, and 60% extenseeffectiveness with 77.8% intense-effectiveness when administered once at a dose of 5% of the fish weight (doses for the active substance of 50 and 40 mg/kg, respectively).
The purpose of the research: to conduct tests of Microsal in composition of 2% medicated feed mixture, which can be prepared in the farm under new conditions of keeping fish in cages (ultimate extinction of heated discharge into heat sink and fish wintering in cages under ice). Materials and methods. Test of 2% medicated feed mixture was conducted at Cherepetskiy rybkhoz Joint Stock Company of Tula region on carp yearlings which were spontaneously infected by bothriocephalus. 4 experimental cages were selected at the 5th pontoon line where about 10 000 of yearling carps with average weighed quantity of 10 g were located. Total weight of fish in each cage was about 100 kg. Before medical and preventive fish processing from each testing cage off at 10 yearling carps had been caught and exposed to helminthological prosection to define extensity and intensity of fish infection by bothriocephalus. On the 6-th day after medical and preventive processing it was also conducted catching and helminthological prosection off at 10 yearling carps to define extenseffectiveness (EE, %) and intenseffectiveness (IE, %) of fish processing by 2% medicated feed mixture with Microsal. Results and discussion. Water temperature at the level of cages lines only by the end of May was 14.8°С because of cold spring. Content of solvable oxygen is 6.2 mg/l. Yearling carps by that time had tiny average weighed quantity and were greatly weakened. Fish infectiousness in cages No 5, 21, 25, and 36 was 40, 40, 50, and 40% respectively while average infection intensity of 1.25-2.0 cestode on one fish. After a single medical and preventive processing yearling carps by 2% medicated feed mixture with microsal (doses on AI 40 mg/kg) 100% processing efficiency was achieved in three cages. In the cage No 21 EE of deworming was 75.0% with intenseffectiveness 71.4%. For receiving high efficiency of medical and preventive fish processing in such type of cage fish farms it is necessary to increase the number of administration of medicated feed (3-5 times), whilst cutting content of microsal in medicated feed from 2% to 0.4-0.5%.
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