Pleurospermum (Apiaceae) is a genus of perennial, rarely biennial herbs. There are about 50 species confined to north Asia, east Europe and especially diverse in the Himalayan region and west China [1]. Pleurospermum brunonis is a perennial herb, 10-15 cm high, found in the temperate regions of Himachal Pradesh and Kashmir at an altitude of 4500-5000 m. The powder of the flowering shoot is mixed with cow's fresh butter and messaged over the entire body to allay fevers, stomatitis and small pox. The dried herb or the garland prepared from the plant is used to protect woolen cloths from the attack of moths and silver fish [2,3]. Coumarins [4-9], saponins [10], flavonoid glycosides [11] and terpenoids [12] have been isolated from various Pleurospermum species. Saponins and sapogenins isolated from P. kamtschatidium have been reported to possess anti-inflammatory, analgesic, antinociceptive and inhibitory effect on NO, PGE 2 and TNF-α release [13]. There is no previous record of chemical investigation on P. brunonis; therefore, the phytochemical examination of ethyl acetate extract of aerial parts of this plant was carried out. The present communication describes the isolation and identification of a new furocoumarin glycoside; 5-O-β-D-glucopyranosyl-6methoxyangelicin (1) along with ferulic acid and angelicin from aerial parts of P. brunonis. Structure of isolated compound was elucidated by the analysis of their spectroscopic data and chemical analysis. The plant material P. brunonis was collected from Daggan Dhar (4200-4300 m asl) Bhalessa, District Doda, India, in July, 2010, The plant species were identified by Dr. Sumer Chand, Systematic Botany Division, FRI, Dehradun, India. The voucher specimen (Hr. no. 61) was deposited in the herbarium of NOTE
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