Objective: Circulating endothelial progenitor cells (EPCs) were shown to be affected in 1 cardiovascular and metabolic diseases. As interventional strategies, hypoxia and exercise are 2 both known to increase the number and enhance the function of EPCs, potentially by 3 extending their lifespan induced by a reduced senescence. Therefore, this pilot study 4 investigated the effect of exercise under normobaric hypoxia on the senescence of EPCs by in 5 vitro cultivation with autologous human serum (AHS).6 Methods: Four healthy trained young males (23 ± 2 years) performed an incremental cycling 7 step test until exhaustion in a normobaric hypoxic-chamber with an average altitude of 4,000 8 m (O 2 12.3%). Blood serum was taken at pre, 10 min post and 4 h post, which was later used 9for in vitro cultivation of EPCs. Senescence was investigated by ß-galactosidase staining.
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