Gram-positive bacteria are an increasingly common cause of community acquired and nosocomial infections, and their resistance to antibiotics is increasing. The recent reports from several continents of methicillin-resistant Staphylococcus aureus with reduced glycopeptide-susceptibility is of grave concern. New agents are required to meet these threats and several classes of compounds are under development. This review focuses on agents that have been recently licensed or are presently in clinical development for the treatment of serious multidrug-resistant staphylococcal, enterococcal and pneumococcal infections, including methicillin-resistant S. aureus and vancomycin-resistant enterococci.
al on behalf of the Collaborative Group. Continuing transmission of sexually transmitted diseases among patients infected with HIV-1 attending genitourinary medicine clinics in England and Wales. BMY 1996;312:539-2. (2 March.) Different diseases indicate different risks of transmission of HIV EDrrOR,-M A Catchpole and colleagues con-1542 BMJ voLuME 312 15juNE 1996
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