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A nonlinear SEIR model is formulated and analyzed. This model accounts for three important interventions — the saturated treatment on infective individuals, the screening on the exposed individuals and the information induced self-protection on susceptible individuals. Existence and stability of equilibria are discussed. A sensitivity analysis for the model parameters is performed and we identified the parameters which are more sensitive to the model system. The sensitivity analysis is further followed up with the two parameters heat plot that determines the regions for the parametric values in which the system is either stable or unstable. Further, an optimal control problem is formulated by considering screening and treatment as control variables and corresponding cost functional is constructed. Using Pontryagin’s Maximum Principle, paths of optimal controls are obtained analytically. A comparative study is conducted numerically to explore and analyze analytical results. We note that in absence of treatment, screening policy may be a cost-effective choice to keep a tab on the disease. However, comprehensive effect of both screening and treatment has a huge impact, which is highly effective and least expensive. It is also noted that treatment is effective for mild epidemic whereas screening has a significant effect on the disease burden while epidemic is severe. For a range of basic reproduction number, effect of self-protection and saturation in treatment is also explored numerically.

The COVID-19 pandemic has resulted in more than 65.5 million infections and 15,14,695 deaths in 212 countries over the last few months. Different drug intervention acting at multiple stages of pathogenesis of COVID-19 can substantially reduce the infection induced, thereby decreasing the mortality. Also population level control strategies can reduce the spread of the COVID-19 substantially. Motivated by these observations, in this work we propose and study a multi scale model linking both within-host and between-host dynamics of COVID-19. Initially the natural history dealing with the disease dynamics is studied. Later comparative effectiveness is performed to understand the efficacy of both the within-host and population level interventions. Findings of this study suggest that a combined strategy involving treatment with drugs such as Arbidol, remdesivir, Lopinavir/Ritonavir that inhibits viral replication and immunotherapies like monoclonal antibodies, along with environmental hygiene and generalized social distancing proved to be the best and optimal in reducing the basic reproduction number and environmental spread of the virus at the population level.

In this study, we develop a mathematical model incorporating age-specific transmission dynamics of COVID-19 to evaluate the role of vaccination and treatment strategies in reducing the size of COVID-19 burden. Initially, we establish the positivity and boundedness of the solutions of the non controlled model and calculate the basic reproduction number and do the stability analysis. We then formulate an optimal control problem with vaccination and treatment as control variables and study the same. Pontryagin’s Minimum Principle is used to obtain the optimal vaccination and treatment rates. Optimal vaccination and treatment policies are analysed for different values of the weight constant associated with the cost of vaccination and different efficacy levels of vaccine. Findings from these suggested that the combined strategies (vaccination and treatment) worked best in minimizing the infection and disease induced mortality. In order to reduce COVID-19 infection and COVID-19 induced deaths to maximum, it was observed that optimal control strategy should be prioritized to the population with age greater than 40 years. Varying the cost of vaccination it was found that sufficient implementation of vaccines (more than 77 %) reduces the size of COVID-19 infections and number of deaths. The infection curves varying the efficacies of the vaccines against infection were also analysed and it was found that higher efficacy of the vaccine resulted in lesser number of infections and COVID induced deaths. The findings would help policymakers to plan effective strategies to contain the size of the COVID-19 pandemic.