In one set of experiments the harvesting was done on the 5th day and in the other on the 6th day. Might this not account for wide variation in the uptake of thymidine? DR. DAVEY In the first group of experiments we did not find any marked difference in the results, whether cultures were harvested at day 5 or day 6, but this is clearly very late in lymphocyte culture time and there tended to be a fairly wide variation. It is late even for antigen stimulation, and I think that in some of the cultures the pH had dropped so much that we were getting rather slight effects. Of the fourteen in Grade II, eight had persistent pain as a result of pressure on a metatarsal remnant, four had discomfort attributed to wound infection, one had persistent hallux rigidus on one side, and in one the cause of pain was not obvious. Review of the Results of Excision of the MetatarsalIn the fifteen in Grade III, the poor results were attributed to irregular resection of the metatarsals in nine, inappropriate operation in three, and no obvious cause in three.The fact that in 80 per cent. of feet operated on symptoms were abolished and the wearing of normal shoes made possible makes this procedure one of the most reliable in the treatment of rheumatoid arthritis. Discussion
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