Three-dimensional framework models are the state of the art to present geologists' understanding of a region in a form that can be used to support planning and decision making. However, there is little information on the uncertainty of such framework models. This paper reports an experiment in which five geologists each produced a framework model of a single region in the east of England. Each modeller was provided with a unique set of borehole observations from which to make their model. Each set was made by withholding five unique validation boreholes from the set of all available boreholes. The models could then be compared with the validation observations. There was no significant between-modeller source of variation in framework model error. There was no evidence of systematic bias in the modelled depth for any unit, and a statistically significant but small tendency for the mean error to increase with depth below the surface. The confidence interval for the predicted height of a surface at a point ranged from ±5.6 m to ±6.4 m. There was some evidence that the variance of the model error increased with depth, but no evidence that it differed between modellers or varied with the number of closeneighbouring boreholes or distance to the outcrop. These results are specific to the area that has been modelled, with relatively simple geology, and reflect the relatively dense set of boreholes available for modelling. The method should be applied under a range of conditions to derive more general conclusions.
Arterial plasma histamine concentrations were measured after exercise in 10 subjects with extrinsic atopic asthma, 10 who were non-atopic and non-asthmatic and seven who were atopic but non-asthmatic, by a single isotope radioenzymatic assay. Significantly higher plasma histamine concentrations were found in the asthmatic subjects before exercise than in the nonatopic controls (p < 0-05). The mean histamine concentration rose after exercise in all groups but the increased levels were not significantly different from pre-exercise values. Similarly, mean circulating basophil counts increased in all groups after exercise, and a highly significant correlation was found between basophil counts and whole blood histamine concentrations (p < 0.001). In vitro studies showed that there was a significant correlation between the number of basophils added to plasma samples and the concentrations of histamine subsequently detected. Although the mean concentrations of plasma histamine and whole blood histamine and number of basophils in the atopic control group were intermediate between those found in the atopic asthmatic and non-atopic controls, none of the differences was significant. Venous plasma histamine concentrations after exercise were measured in a further five subjects with extrinsic atopic asthma and five non-atopic, non-asthmatic subjects before and after exercise with the more sensitive and specific double isotope radioenzymatic assay. Concentrations of plasma histamine measured by this assay were about one tenth of those measured by the single isotope radioenzymatic assay. Although a small rise in mean plasma histamine concentration occurred in both groups after exercise there was no significant difference in these levels either between or within the groups. We find no evidence from these studies on measurement of peripheral blood histamine to support the hypothesis that mast cell mediator release is implicated in the pathogenesis of exercise induced asthma.Exercise induced asthma is a phenomenon which can be demonstrated in varying proportions of patients with both extrinsic atopic asthma and cryptogenic non-atopic asthma.' Several observations suggest that mast cells and their mediators may play a part in the pathogenesis. A short refractory period occurs after an episode of exercise induced asthma, during which exercise can no longer lead to airflow obstruction, suggesting the possibility of depletion of mediator stores from mast cells.2 Sodium cromoglycate, a drug thought to act by stabilising
SummaryRecent advances in medical technology enable many children with complex disabilities to survive into adulthood and to have certain expectations of life. One of these expectations is the continuity of specialist health care in an adult setting. This paper describes a new out-patient service which aims to provide optimum care, continuity and consistency of service for adults with spina bifida and/or hydrocephalus. The need for specialist health input into this service, in order to monitor the neurological, urological and psychosocial complications often associated with spina bifida and/or hydrocephalus is recognised. In one year (1992), 86 young adults with spina bifida and/or hydrocephalus attended for annual or more frequent assessment, either independently or with their families or carers. A variety of health and social problems were treated. In response to demand, a multidisciplinary assessment unit, which includes the services of both medical and nursing specialists, occupational and physiotherapists, psychologists and access to specialist surgical opinions has recently opened at the Chelsea and Westminster Hospital. This new service attempts to meet some of the needs described in the outpatient audit. Adults with other disabilities are requesting to use this service. A longitudinal study to monitor quality, and outcome is indicated from this initial survey.
The paper describes results to date of a continuing monitoring study of coastal 'soft cliff' recession at the British Geological Survey's (BGS's) Coastal Landslide Observatory (CLO) on the east coast of England at Aldbrough, East Riding of Yorkshire. The cliffed site, part of the 50 km long Holderness coast, consists of glacial deposits, and is one of the most rapidly eroding coastlines in Europe. This rapid rate of erosion provides an ideal opportunity for observation and process understanding because it facilitates the collection of data over periods of time encompassing significant new landslide events at the same location. The results of two approaches are reported: first, terrestrial Light Detection and Ranging (LiDAR) surveying (TLS); second, the installation of instrumented boreholes. The aim of the research is to combine these to investigate the role of landslides and their pre-conditioning factors and the influence of geology, geotechnics, topography and environmental factors on cliff recession. To date, an average recession rate of 1.8 m a −1 and a maximum rate of 3.4 m a −1 have been recorded for the site. The establishment of the CLO and its conceptual geological-geotechnical model are described in a related paper.
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