The role of radiotherapy either as adjuvant or as primary treatment remains to be demonstrated in prospective randomised studies. From our results, it seems that high radiation doses could be dangerous and could detriment prognosis. Brachytherapy boost was not superior to treatment with external beam irradiation alone.
to 76%). The overall SA CC rate increased by 37.63% (range per province: 1.85% to 61.63%) in period 2. The Northern Cape however showed a decline in CC's by 28.3%. There was an overall 20.3% increase of incidental gallbladder cancer (iGBC) in period 2 (59 to 74 cases) in SA. The Northern Cape had a 900% decrease in incidental gallbladder cancer in period 2 (10 cases to 1 case). Three other provinces also showed smaller decreases in iGBC (Gauteng 24 to 20 cases; Mpumalanga 4 to 2 cases; Limpopo 1 to 0 cases). Conclusion: This study suggests that living in a rural area is protective from symptomatic gallbladder disease and possibly from gallbladder cancer.
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