BackgroundIntra-articular adhesion is one of the common complications of post knee surgery and injury. The formation of joint adhesion can lead to serious dysfunction. Rosuvastatin (ROS) is a new 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, with multiple biological effects. In our study, the object was to evaluate the effectiveness of ROS in the prevention of post-operative knee adhesion in rats.Material/MethodsFemoral condyle exposing surgery was performed on 45 healthy Sprague Dawley rats. Gelatin sponges soaked with 20 mg/kg of ROS, 10 mg/kg of ROS, or saline were used to cover the surgical site. The post-operative knee joints were fixed in a flexed position with micro Kirschner wires for four weeks. ROS effectiveness for treating intra-articular adhesion was determined with visual score evaluation, hydroxyproline content, histological analyses, immunohistochemistry, and inflammatory and vascular endothelial growth factors expression.ResultsThe animals’ recovery was stable after surgery. The hydroxyproline content, visual score, and inflammatory vascular growth factors expression levels suggested that, compared with the control group, the ROS treatment groups showed better outcomes. ROS prevented joint adhesion formation, collagen deposition, and vascularization at the surgical site, and also inhibited inflammatory activity post-operatively. Compared with the 10 mg/kg ROS group, the 20 mg/kg ROS group showed significantly better outcomes.ConclusionsThe local application of ROS reduced intra-articular adhesion formation, collagen deposition, and vascularization at the surgical site, and inhibited inflammatory activity post-operatively. These results suggested optimal concentration of ROS to be 20 mg/kg.
Background.Treatment tactics of proximal humerus fractures remains a matter of dispute due to multiple cases of unsatisfactory outcomes and high rate of postoperative complications.The aim of the study—to evaluate midterm outcomes of intramedullary fixation for treatment the proximal humerus fractures in comparison with plate fixation.Material and Methods.The authors evaluated treatment outcomes of 175 patients with proximal humerus fractures who underwent surgery in the period from 2012 to 2017. Depending on the fixation method the patients were divided into two groups: the main group consisted of 107 patients who underwent intramedullary fixation by a nail of third generation; a comparison group — consisting of 68 patients who underwent fixation by a locking plate with angular stability.Results.In one year after intramedullary nail fixation the authors observed the excellent and good outcomes on Constant scale in 83.2% of cases, satisfactory — 12.1%, unsatisfactory — 4.7%. Patients who underwent plate fixation demonstrated the following outcomes: excellent and good — 73.5%, satisfactory — 17.7%, unsatisfactory — in 8.8%. Constant score increase was equal in the main and control groups and varied depending on the fracture type.Conclusion.Intramedullary nailing is an option for treatment of all fracture types of proximal humerus as well as for the cases of combined humeral neck and diaphysis fractures. Functional recovery parameters were higher in the main group of patients after intramedullary nailing.
Нестабильные повреждения тазового кольца продолжают оставаться одной из наиболее частых причин летального исхода у пациентов с сочетанной травмой, а существующие способы имеют ряд осложнений и противопоказаний. Нами описан успешный клинический случай остановки внутритазового кровотечения у пациента с множественными травмами, в котором с целью объединения преимуществ малой инвазивности ангиоэмболизации, простоты исполнения и воздействия на основную причину кровопотери тампонады таза применен новый способ внутритазовой остановки кровотечения при помощи баллонных устройств. Ключевые слова: сочетанная травма, множественная травма, политравма, переломы костей таза, внутритазовое кровотечение, тампонада таза Для корреспонденции: Артём Михайлович Лыско ул. Хачатуряна, д. 12, корп. 3, г. Москва, 127562; ArtLysko@gmail.com 1 Российский национальный исследовательский медицинский университет имени Н. И. Пирогова, Москва, Россия 2 Северо-Западный государственный медицинский университет имени И. И. Мечникова, Санкт-Петербург, Россия Статья получена: 03.03.Unstable pelvic ring fractures are one of the common causes of death of patients with concomitant injuries. The existing methods applied to treat such conditions can cause a number of complications and have contraindications. We have described a successful clinical case of intrapelvic hemorrhage arrest in a patient with multiple injuries. in this case, we applied the new method combining minimally invasive angioembolization and easily applicable and effective balloon tamponade.
The question of the performance of one step operation in patients with concomitant and multiple trauma from the point of view of the choice of surgical intervention time, sequence and type of operation is considered. The advantages of one step operation include: one narcosis, one postoperative period, decrease of the risk of posttraumatic and postoperative complications, easing of treatment and nursing at intensive care unit as well as earlier rehabilitation. Criteria for the detection of the surgery time, sequence and type of operative intervention for individual patient with polytrauma were elaborated. Between 1998 and 2002, 282 one-step operations (71 emergency operations (within 5 hours after trauma), 135 urgent operations (within the first 3 days after trauma) and 76 delayed operations (within 10-14 days after trauma)) were performed at Moscow clinical Hospital #1 named after IV. I. Pirogov.
Unstable pelvic ring fractures are one of the common causes of death of patients with concomitant injuries. The existing methods applied to treat such conditions can cause a number of complications and have contraindications. We have described a successful clinical case of intrapelvic hemorrhage arrest in a patient with multiple injuries. in this case, we applied the new method combining minimally invasive angioembolization and easily applicable and effective balloon tamponade.
Results of treatment of 112 patients were analyzed. All patients were treated at the Moscow Clinical Hospital named after N.l. Pirogov during the period from 1998 to 2002. Fifty-four patients had I and 11 type, 38 - IIIA, 14 - IIIB and 6 patients - IIIC type of fractures by Gustilo classification. Tactics of treatment was defined by patient's general condition and the degree of soft tissue injury. In fractures of I and II type primary UTN osteosynthesis was preferable; in fractures of IIIA type primary osteosynthesis with AO rod device or Piless device followed by final UTN osteosynthesis were performed. In fractures of IIIB type osteosynthesis was carried out using device. To all patients with fractures of IIIC type the limb amputation was performed. Healing by first intention took place in fractures of I and II type. In fractures of IIIA and IIIB type the open management of wound with following closure during sequential debridement was preferred. When tibia necrosis developed, the resection in fractures zone with following early defect substitution by IHzarov technique was carried out.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.