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Spontaneous development of tumors in 5086 Holtzman-source rats ranging in age from 1 to 18 months is reviewed. Overall incidence of tumors was 4.3% (8.2% for females, 2.3% for males). Statistical analysis of the data demonstrated that the potentiality for tumors was comparable to previously reported lifetime studies. Characteristics of development of tumors are given, and the more uncommon tumors are described briefly. The occurrence of tumors in young rats in this survey indicates the need for accumulating data on tumors in other than “old” rats as an aid in interpreting data obtained from toxicological studies.

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h series of 133 2 4 2-pyridyl)-1,2-diarylalkanols, or compounds closely related to them, were synthesized and assayed for their hypocholesteremic and estrogenic activities in rats. Many of these compounds were active in both tests, but there is no necessary correlation between the two effects. Compound 16 was selected for preclinical toxicologic study, followed by a study of its hypocholesteremic effect in man. The compound selected was remarkably nontoxic in all species studied, but it had no hypocholesteremic el'fect in the dog, the monkey, or in man.