of phosphocreatine have been determined in specimens of about 0*1 g. brain without chemical separation. 2. After death, a very rapid fall in phosphocreatine and rise in inorganic phosphate takes place in the brain of guinea pig as of other species. 3. On slicing brain cortex and allowing the slices to respire with glucose under normal metabolic conditions, the inorganic phosphate falls and the phosphocreatine rises until the concentrations approach those normal to the tissue in vivo. 4. The concentrations reached vary with the metabolic mixture. REFERENCES
t-Butyllithium and t- butylmagnesium chloride cyanocuprates were used to prepare 4(6)-t- butylpyrimidines from the corresponding 4(6)-halopyrimidines . The highly hindered 2,4,5-tri-t-butyl-6-chloropyrimidine, containing an ortho-di-t-butyl arrangement, was prepared by this method. No alkyl group isomerization was observed but some substrate reduction was detected.
The mixed higher‐order organocuprate (II), formed by adding of 2 equiv. BuLi to 1 equiv. of CuCN, is used to prepare the 4,6‐di‐tert.‐butylpyrimidines (III) from the readily available iodo‐pyrimidines (I).
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.