Background: Angiotensin Converting Enzyme inhibitors (ACEis) and beta-blockers (BB) are suggested to prevent and treat trastuzumab-related cardiac toxicity. We performed a prospective clinical trial in women experiencing mild cardiac toxicity (MCT) while on adjuvant treatment with trastuzumab. Methods: MCT was defined as an asymptomatic absolute decrease in LVEF of ≥ 10 percentage units to >50%. Treatment consisted of enalapril 2.5 mg bid and carvedilol 3.75 mg bid, which were up-titrated to 10 mg bid for the enalapril and 6.25 mg bid of carvedilol. In patients receiving study drug, the primary study end-point was LVEF recovery, which was defined as a post-trastuzumab LVEF returning to no less than −5 percentage points of the baseline value. Results: 103 patients were enrolled, 100 started trastuzumab, and 98 completed the planned treatment. Sixteen patients (16%) had MCT and received study drugs until trastuzumab completion. None of these patients achieved a post-trastuzumab LVEF recovery. Nevertheless, treated patients had significantly higher median LVEF recovery from nadir to post-trastuzumab LVEF in (8% points vs. 4% points, respectively, p = 0.004), resulting in no difference in post-treatment LVEF values compared to patients without MCT. Conclusion: Treatment of MCT with ACEis and BB allows faster LVEF recovery from nadir values and should be further studied in this setting.
IntroductionThe suicidal behaviours constitute a significant problem in terms of public health, thus a major goal of the WHO is to reduce these behaviours.In the '80s suicide rates and suicide attempts in the Trieste were the highest in Italy, comparable with those of Central Europe. Since the '90s a project was launched to prevent suicidal behaviour and suicide rates and non-lethal self-harm gestures have plummeted.ObjectivesWe study the sociodemographic variables of this phenomenon.AimsThe aim of our study is to monitor the performance of non-lethal self-harm over time and identify evidences to implement prevention strategiesMethodsWe conducted retrospective study in the period 01.01.2000- 31.12.2007.We analyzed the records of hospital emergency rooms in Trieste, screened according to the keywords that indicate the diagnosis of access “self-harm” and “voluntary intoxication”.Socio-demographic variables were stratified by age and gender.Outcome variables were evaluated. Data were compared with those of a study conducted from 1993 to 1990.ResultsThe study showed a mean of 85/100,000 inhabitants. The methods most frequently used were drug intoxication and cutting. There was a reduction in hospitalisations rates and an increased number of appointments in the Mental Health Department by the subjects with a suicide attempt history.ConclusionsThe rates of non-lethal self-harm in the period considered decreased compared to the '80s, while the average age of those who commit the act increased. These data can be used to enhance the primary and secondary prevention strategies.
Introduction: Spices-use is continuously increasing in Western Countries, especially for legal reasons. Intoxication has been widely associated with psychotic symptoms. Objectives: Here we present a case-report that seems to highlight this possible association between canabimimetics and psychosis, stressing the use of 'Spices" as an instrument of auto-determination in the young patient's opinion. Aims: Find if the supposed relation between certain Life Events and Spices use for people with a use consequent to a Dependent Personality traits can lead to an unmasking of a psychosis. Methods: Clinical interviews, Eri-Raos, drug-use and literature revision. Results: Diagnostically, these patient presented right after a Spice intoxication psychotic symptoms like delusions, strong distress, the feeling of being observed and considered 'mad", self-isolation that strengthened the need of Spice use and more difficulty (but self-reported need) to stay with others and to self-determinate herself in meaningful relationships. These symptoms have had a strong relief after the establishment of a relationship with our community mental health center (CMHC) and its multidisciplinary staff, that took care whit the patient of the whole life, in particular of the details that were stressful for her. Conclusions: This report, being in accordance with others, suggests the necessity of further studies on the relation between Spice-use and psychotic symptoms, in particular for patients with a use that has roots to Dependent Personality Traits.
IntroductionThe rate of non fatal self-injurious behaviour in young people has increase in recent years. Non fatal self-injurious behaviour such as cutting oneself and abuse of substance is often performed without suicidal intent to cope with emotional distress although it is well known to have a close association with future suicidal behaviour.ObjectivesEvaluating people under 29's suicidal behaviours' rates.AimsMonitoring developments in not lethal self injurious behaviour in the population of adolescents and young adults in Trieste to identify strategies that will guide the prevention of suicidal behaviour in this age group.MethodsRetrospective study based on verbal access to emergency, extracts under the headings “self-harm” and “poisoning” during period 2000-2007. We considered as variables the calculation of rates for the age groups 15-19 and 20-29 years, mode of self-injurious act coded according to the parameters of the ICD-10.ResultsThe average rate for the age group 15-19 years was found to be 0.5 cases per 100,000 inhabitants, while for ages 20-29 was found to be 1.3 cases per 100,000 inhabitants. There wasn't a significant difference between the two genders.The methods most frequently adopted were found to be voluntary intoxication and cutting.ConclusionsTo counter the fragility and risk of self-harm and suicide in adolescents and young adults, our Local Health Company launched in 2014 a dedicated website. The site provides information on the types of conditions that may affect the target population and the self-destructive behaviors.
IntroductionA review of the literature shows that the self-injurious behaviours are more common among females, and suicides among male subjects. A significant difference between the two genders is also reflected in the choice of means used to commit the act of self-injuring, considering the male gender predilection for more violent means.Some recent studies indicate trends that deviate from the above data in the literature or indicate a tendency to an attenuation of these differences.ObjectivesReasons for engaging in self-harm behaviours include to regulate emotion and to elicit attention. Correlates of these practices include a history of sexual abuse, depression, anxiety, alexithymia, hostility, smoking, dissociation, suicidal ideation, and suicidal behaviors.Aims:the aim of this study is to evaluate the gender difference in self-injurious behaviour.MethodsOur retrospective study was conducted making a comparison between a period of time before and after the start of an articulated program of prevention of suicidal behaviors in Trieste, from 1983 to 2007.ResultsIn the '80, the self-injurious behavior were more common among males; after 2000 years this difference has continuously attenuated. This trend is in contrast with findings in the international literature.Even the repeated acts of self-harm were more common among males.Regarding the data on suicides, they were more frequent in male subjects, and this fact has remained stable over time, in accordance with international data.ConclusionsMore studies are necessary to evaluate gender difference in self-injurious behaviour.
IntroductionThe Compulsory Health Treatment (TSO) is an action applicable in case of justified need and clinic emergency, in presence of the refusal to Health Treatment Volunteer (TSV) in a subject suffering from specific illnesses, among which there are severe psychiatric illnesses.ObjectivesThe TSO is the subject of discussion, because it's actually an action that violates – even if only temporarily – the free will of the person. It's a procedure justified by the impossibility of applying alternative practices that ensure a speedy recovery to the subject of his psychic integrity, consistent with the need of the person.AimThe aim of this study is to evaluate the epidemiology of TSO in Trieste between 2011 and 2013.MethodsThis retrospective study was conducted on 74 TSO performed at the CMHC and the Emergency Unit of Trieste, on 71 people (22 women, 49 men). Data analysis were on gender, diagnosis, TSO's days' number, frequency and significant changes during the TSO, with a comparison of these variables between the data of 2011, 2012 and 2013.ResultsThe number of people under TSO was the same in the three years, with a countertrend of gender (decrease of 30% of women; increase of 46% of men). There was a decrease about days of TSO in the three years.ConclusionIt's necessary to implement practices that promote good cooperation from the subject, to establish a contractuality which allows to limit TSO only for time strictly necessary.
IntroductionSporting practice for psychotic patients have been demonstrated to be efficacious as a rehabilitation tool at various levels, improving social interaction, self esteem, body self consciousness, reduce anxiety and depression, reduce stigma, improve compliance, reduce admission rates, reduce aggressiveness, reduce family burden.Since 1999 the Fuoric'entro Polisportiva was founded in Trieste, with the support of the Department of Metal Health, with the aim of influencing recovery at several levels.ObjectivesEvaluate the impact on participants' health.AimsDemonstrate the outcome of the rehabilitation program based upon the sporting activity.MethodsThe research is a descriptive, case-control study, led on 40 patients (20 cases and 20 controls) followed by the Trieste's Metal Health Department. We considered as items living situation, professional condition, gender and age, diagnosis, therapy and its compliance, admissions’ number and duration, main therapeutic interventions, following up a previous study on the same rehabilitation program.ResultsIn the cases’ group there is a stable improvement of the professional and living conditions, compliance and a reduction of admissions’ number and duration.ConclusionsA rehabilitation program based on sporting can improve coping abilities, psychopathological conditions, person's 'social functioning”, family burden.
Introduction: Narcissistic Personality Disorder (NPD) has a prevalence of 6,2% on general population, with greater rates for men (7,7%) than women (4,8%). It has been frequently associated with substance misuse, Bipolar Disorder (type I and II), anxiety and other personality disorders, but seldom it has been associated with Major Depressive Disorder. Objectives: The emphasis put on sex by elder people with NPD hasn't been widely studied in Literature. Frustration on the maintenance of a fixed rate of weekly sexual intercourse with their partners has led to a MDD in two outpatients that, for this reason, came to our Community Mental Health Center (CMHC). Aims: Find if the supposed relation between certain Life Events for people with a well-controlled NPD can lead to a MDD can be detected. Methods: Both completed the Minnesota Multiphasic Personality Inventory (MMPI-II) that confirmed the coexistence. Results: Diagnostically, these patients presented an exaggerated self-appraisal even during the depressive phases, attempts to gain others' approval and attention, very little interest on others' thoughts and efforts to gain personal advantages in a depressive frame. Conclusions: This report suggest the necessity of further studies on the relation between NPD and MDD when a kind of frustration in important fields of patients' life occurs.
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