synopsisThe circular dichroihm ((31)) spectra of complexes of I)NA with ethidium bromide, proflavine, 9-aminoacridirie and 4-ethyl-9-amino-acridirie have been determined hetween 220 arid 4.70 rim, the range being extended to 600 nm for ethidium bromide. The variation of the magnitude of the visible and near--ultraviolet CD spectra of ethidium bromide-DNA complexes with the amoiint of ligand bound (7) suggests a cnmmon binding position with proflavine. On the other hand, 4-ethyl-9-aminoscridine complexed to DNA shows CD spectra not distinguishable from those of 9-aminoacridine in both the visible and ultraviolet. The interpretation of these resiilts with respect to the stereochemistry of the 1)NA-ligand complexes is discussed.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.