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ACHN-490 is an aminoglycoside with activity against multidrug-resistant pathogens, including those resistant to currently used aminoglycosides. Two randomized, double-blind, placebo-controlled clinical studies investigated the pharmacokinetics (PK), safety, and tolerability of ACHN-490 injection in healthy subjects. Study 1 used a parallel-group design with escalating single (SD) and multiple doses (MD). Study 2 explored a longer duration of the highest dose tolerated in the first study. Subjects were randomly assigned to receive either ACHN-490 injection or a placebo administered by a 10-min intravenous infusion. Study 1 enrolled 39 subjects (30 active and 9 placebo) and consisted of a single dose of 1 mg/kg body weight followed by ascending SD and MD cohorts of 4, 7, 11, and 15 mg/kg for 10, 10, 5, and 3 days, respectively. Study 2 enrolled 8 subjects

The 12 GeV Upgrade at Jefferson Lab requires a new particle spectrometer for precision Nuclear Physics studies at the highest electron momentum available. This new spectrometer the Super High Momentum Spectrometer (SHMS) operating at 11 GeV/c will be built in Hall C to work in coincidence with the present device, the 7.5 GeV/c High Momentum Spectrometer (HMS). The SHMS design requires five new SC magnets arranged as dipole, quad, quad, quad, dipole or dQQQD. The "d" is a small 3.1 T, SC dipole providing an initial 3.5 degree bend which allows the SHMS to reach a 5.5 degree scattering angle and provide enough clearance for the other much larger magnets of the SHMS. The first SC quad is an upgraded version of the HMS Q1 quad running at 10.7 T/m in a 40 cm warm bore with a 1.86 m EFL. The second and third quads are a pair of a completely new design, 60 cm warm bore, 14.4 T/m, 1.6 m EFL cosine22 SC quadrupole. Finally, the main dipole is a 60 cm warm bore 4.5 T, 2.85 m EFL magnet that provides the momentum analysis for the SHMS. This project is on schedule for the start of commercial procurement beginning in FY2009 to support start of Physics with the SHMS in 2014. The final design details of these four unique magnets will be presented including the coil design, magnetic design, force collar, and cryostat.