Periodontal disease is a complex multifactorial inflammatory disease in which some specific microbial pathogens have been implicated in its pathophysiology namely Aggregatibacter actinomycetemcomitans, Tannerella forsythia and Porphyromonasgingivalis. This review focuses on A. Actinomycetemcomitans, a gram negative micro-oraganisms and its role as one of the causative microorganisms of periodontitis, its interaction with the host, other oral micro flora and drugs including its association with extraoral diseases.
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