The present investigation was aimed to improve the dissolution rate of the poorly soluble drug simvastatin, by formulating it as a liquisolid compact. Different liquisolid compacts were prepared using mathematical formulae to calculate the required quantities of powder and liquid ingredients to produce acceptably flow able and compressible admixture. Aerosil-200, Syliod-244FP and Syliod-244FP and MCC, Lactose were employed coating and carrier material, non-volatile ((PEG 200) liquid vehicle, respectively. The various ratios of drug to liquid and carrier to coating were used to prepare liquisolid compacts. The formulated liquisolid tablets were evaluated for all pre compression and post compression parameters. The in vitro release characteristics of the liquisolid compacts as formulated by direct compression. The tableting properties of the liquisolid compacts were within the acceptable all standard limits and drug release rates were distinctly higher as compared to directly compressed tablets. The FTIR spectra showed no interaction between drug-excipient and disappearance of the characteristic absorption band of simvastatin in liquisolid formulations could be attributed to the formation of hydrogen bonding between the drug and liquid vehicle, which resulted in dissolution enhancement. Thus, the liquisolid technique was found to be a promising approach for improving the dissolution rate and solubility rate of a poorly soluble drug like simvastatin.
To evaluate fast dissolving tablets for Roflumilast employing with novel
superdisintegrant using lepidium sativum mucilage by using 23 factorial design.The physical,
chemical and micromeritic studies were evaluated for the prepared mucilage. To estabish fast
dissolving tablets of Roflumilast with lepidium sativum mucilage ie a superdisinitegrant in
different ratios by using direct compression method employing 23 factorial design. All the fast
dissolving tablets were evaluated pre compression and post compression parameters like
dissolution efficiency (DE%) percent of drug dissolved at 5 min (PD5). The Lepidium sativum
mucilage was to be found fine,free flowing crystaline powder and excellent swelling nature in
water. The FTIR and DSC studies were indicated to no interactions between roflumilast and
Lepidium sativum mucilage. All the formulation batches shows good quality with regrad to
drug content (98±0.092 to 100±0.026)hardness(3.4±0.43 to 3.6±0.64)friability (0.21±0.04 to
0.88±0.42). The optimized formulation batch shows less disintegrant time (52±0.24). The In–
Vitro wetting time was less (i.e., 90s) in optimized formulation F2. The water absorption ratio
of the formulated tablets was found to be in the range of (90.3±0.027 ). The cumulative drug
dissolved in the optimized formulation F2 was found to be ( 99%) in 5 min. Lepidium sativum
mucilage was found to be a super disintegrant which enhanced the dissolution efficiency when
combined with Crospovidone, croscarmellose sodium, and hence it could be used in the
formulation of fast dissolving tablets to provide immediate release of the contained drug within
5 min.
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