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Fused pyrimidine derivatives R 0515Novel Synthesis and Biological Activity Study of Pyrimido[2,1-b]benzothiazoles. -10 Title compounds are prepared and screened for their antimicrobial and antifungal activities. (IIIa), (IIId), and (IIIf) show good activity against Candida albicans and (IIIf) also against Staphylococcus aureus. -(GUPTA*, S.; AJMERA, N.; GAUTAM, N.; SHARMA, R.; GAUTAM, D. C.; Indian J. Chem., Sect. B: Org. Chem. Incl. Med. Chem. 48 (2009) 6, 853-857; Dep. Chem., Univ. Rajasthan, Jaipur 302 004, India; Eng.) -M. Bohle 42-166

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The present communication deals with the synthesis of a series of fluorinated 10H-phenothiazines. 10H-phenothiazines is prepared by Smiles rearrangement of substituted 2-foramido-2´-nitrodiphenylsulfide. Substituted 2-foramido-2´-nitrodiphenylsulfide were obtained by the reaction of 2-amino-3-fluorobenzenethiol witho-halonitrobenzenes followed by formylation and 1-nitro/1-halo-10H-phenothiazines have been prepared by the reaction of substituted 2-aminobenzenethiols with reactiveo-halonitrobenzene containing a nitro group or halogen atom ato-position to the reactive halogen atom directly yielded 1-nitro/1-halo-10H-phenothiazines in situ. 10H-phenothiazine sulfone derivatives have been synthesized by the oxidation of 10H-phenothiazines by 30% hydrogen peroxide in glacial acetic acid. The structure of the synthesized compounds has been characterized by spectroscopic data and elemental analysis. Antimicrobial studies of the synthesized compounds have also been included.

This article deals with the synthesis and antimicrobial activity of a series of novel substituted 10H-phenothiazines, their ribofuranosides, and sulfone derivatives. 10H-Phenothiazines were prepared by Smiles rearrangement. These prepared phenothiazines were used as the base to prepare ribofuranosides by treatment with sugar (1-O-acetyl-2,3,5-tri-O-benzoylribofuranose). Sulfone derivatives were prepared by the oxidation of 10H-phenothiazines. The structure of the synthesized compounds was established by elemental analysis and spectroscopic data.