A measured force resolution of 5.6×10−18 N/Hz at 4.8 K in vacuum using a single-crystal silicon cantilever only 600 Å thick is demonstrated. The spring constant of this cantilever was 6.5×10−6 N/m, or more than 1000 times smaller than that of typical atomic force microscope cantilevers. The cantilever fabrication includes the integration of in-line tips so that the cantilever can be oriented perpendicular to a sample surface. This orientation helps suppress cantilever snap-in so that high force sensitivity can be realized for tip-sample distances less than 100 Å.

Unselected patients with advanced NSCLC and PS 2 are best treated with combination chemotherapy as first-line therapy. Erlotinib may be considered in patients selected by clinical or molecular markers.

A magnetic resonance force microscope with a “tip-on-cantilever” configuration was used to compare imaging characteristics of paramagnetic and ferromagnetic samples. Three-dimensional electron paramagnetic resonance (EPR) imaging of diphenylpicrylhydrazil (DPPH) particles was accomplished by scanning the sample in two dimensions while stepping an external field. The EPR force map showed broad response reflecting the size and shape of the sample, allowing a three-dimensional real-space magnetization image to be successfully reconstructed. In contrast to the EPR case, ferromagnetic resonance imaging of a micron-scale yttrium iron garnet sample showed no significant line broadening despite the strong field gradient (∼10 G/μm). Two-dimensional force maps revealed spatial dependence of magnetostatic and magnetoelastic modes.