The presence of prestroke cerebrovascular disease and severity of WMD are associated with worse SDB. These findings suggest that either white matter is particularly vulnerable to the hypoxia and blood pressure variability associated with SDB or that WMD is a major factor exacerbating SDB following stroke.
We report MRI findings in a patient with familial hemiplegic migraine (FHM) with repeated episodes of hemiparesis. FHM is caused by a penetrant autosomal dominant genetic mutation; several mutations have been genotyped, involving brain-expressed ion channels. We found cerebral oedema, dilatation of intracerebral vessels and decreased water diffusion contralateral to the hemiparesis, not respecting vascular territories, with subsequent complete resolution of both clinical and imaging abnormalities. These results are thought to be consistent with an underlying primary neuronal pathology with secondary vascular effects, as opposed to the traditional, primarily vascular, model of migraine aetiology.
Cerebral sinus thrombosis (CST) can cause cerebral venous infarcts, frequently hemorrhagic. CST has many etiologies including otitis media, trauma, pregnancy, hypercoagulable states, and cancer. Systemic thrombosis is well recognized in cancer patients because of associated hypercoagulability, metastatic spread, and direct tumor infiltration and as a complication of chemotherapy. 1 Tamoxifen, a selective estrogen-receptor modulator, is the most common hormonal therapy in the treatment and prophylaxis of breast cancer. One of its known side effects is systemic thromboembolic events. 2 Recently, two reports have related tamoxifen to CST in absence of other risk factors. 3,4 To confirm this association, we report two patients receiving tamoxifen treatment who developed CST.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.