BackgroundMaladaptive behaviors and cognitive impairment can be main problems in patients with Prader-Willi Syndrome. Understanding difficulties underlying the maladaptive behavior through early diagnosis and management allow tremendous improvement in the whole clinical picture.AimTo study the psychobehavioral deviations in a sample of Egyptian children with Prader-Willi syndrome and possible relation to genotype.MethodsWe included 15 out of 72 patients of both sexes, aged from 5–15 years old from the National Research Centre. All patient were fulfilling the diagnostic threshold of modified list of Prader-Willi criteria. Detailed cytogenetic analysis was done using: conventional cytogenetic analysis of peripheral blood lymphocytes and Fluorescent in Situ Hybridization. Cognitive and psychological profile of Patients were assessed usingstandard and semi structured psychiatric sheet and interviewWechsler Intelligence Scale for Children,Child Behavior Checklist for ages 4–18years,Conner’s’ Parent Rating Scale-Revised; long version,Childhood Autism Rating Scale.Results66.7 % of the patients were deletion positive and 33.3% were negative. 100% of the sample were mentally subnormal. 26.3% had autistic symptoms ranging from features to severe form, all were deletion negative. High prevalence of inattention, hyperactivity, anxiety, social, cognitive and behavioral problems were evident in the patients, manifested in more frequency and severity in non-deletion patients.ConclusionCognitive and psychological challenges were evident in PWS patients’. There were some clinical differences according to different genotypes.
BackgroundChildren with autism have developmental motor profile that differ from other healthy children. This is evident since early childhood, sometime noted by parents and neglected by clinicians. These motor deficits are related to other domains of dysfunction in children with autism as social and language skills .Improving motor deficits can help better prognosis for these children.AimTo detect motor deficits in a sample of autistic children and correlate them with the severity of autistic symptoms.MethodsWe recruited 20 autistic children ranging from 3 to 6 yrs from the Institute of psychiatry outpatient child psychiatry and rehabilitation clinics of Ain-Shams university hospital .We excluded patients having total intelligence less than 75 or having other developmental disorder. We matched them with healthy controls for age and sex and compared both motor development and self help skills using Brigance scale. We confirmed diagnosis of autism in each patient by applying ICD-10 criteria of autism by a senior psychiatrist and by having a Childhood Autism Rating Scale (CARS) score above 30. Relation of autism severity and motor deficits was assessed later by Correlation co-efficient test.ResultsCompared to controls, autistic children showed statistically significant low Brigance test scores on; gross movement, fine movement and self-help skills subdomains .Motor delay was significantly correlated with the severity of autism.ConclusionsMotor deficits were evident in autistic patients and could indicate severity
Conclusions: Dex has stimulated cell motility and migration potential of all BC cells types, the most therapeutically unfavorable effect on metastasis promotion was observed for triple negative BC cells. CpdA keeps all benefits of GC with no effects on TA and migration potential of BC cells. Legal entity responsible for the study:
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