The absolute configuration of natural ( +)-a-lipoic acid is confirmed to be R by the synthesis of its enantiomer from (S)-malic acid.cc-( +)-Lipoic acid, the coenzyme for a-ketoacid dehydrogenases,l was assigned the (R)-configuration (la) by Mislow and Meluch,2 by comparison of the melting point-composition diagrams for mixtures of (R)-( +)-3-methyloctanedioic acid with (+)-and with (-)-3-mercapto-octanedioic acid, respectively. By synthesis, these mercapto-diacids had been correl-
11 Alkylcobaloximes substituted with an ester function at the 1-position of the u alkyl group can be prepared by treating cobaloxime-12 w-Carboxyalkylcobalatnlns can be prepared in very low yield (based on carboxylic acid) by trcating a carboxylic acid with cob(I1)-
1. Das aus dem Dimethyltartrat (Ia) erhältliche (Literaturangaben) Dioxolan (II) wird in das [vom Nebenprodukt (III) abtrennbare] Diol (IV) übergeführt, dessen Hydrierungsprodukt (V) nach bekanntem Verfahren in (R)‐Ethyloxiran (VI) übergeführt wird.
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