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Telbivudine, an FDA pregnancy category B drug, has been found to reduce hepatitis B virus (HBV) perinatal transmission with no safety concerns in infants aged up to 1 year. This study evaluated the long-term efficacy and safety of telbivudine in 214 infants born to 210 pregnant women with chronic hepatitis B infection who were treated with telbivudine during pregnancy (weeks 20-32 of gestation). The infants were followed for up to 5 years after birth. The efficacy endpoint was the rate of perinatal transmission, which was established by HBsAg and HBV DNA levels at 7 and 12 months. Safety endpoints included head circumference, weight, height, congenital abnormality and hospitalization rates. In addition, the Denver Developmental Screening Test was performed in 92 randomly selected infants. None of the 214 infants born to these women were infected with HBV, and all had effective serum hepatitis B surface antibody (HBsAb) levels. Compared with Chinese standard values, there were few differences in the infants' mean head circumference, weight, and height values. No birth defects were diagnosed, and the congenital abnormality rate was 0.934%. Serious adverse events requiring hospitalization occurred in 20 infants (9.35%). The qualified Denver Developmental Screening Test rate in 92 infants was 97.82%, which was comparable to a rate of 92% in normal Chinese children. Thus, treatment with telbivudine during the second or third trimesters of pregnancy safely blocked perinatal transmission of HBV. Infants born to telbivudine-treated mothers showed normal growth and development during long-term follow-up of up to 5 years.

With the increasing diversification and personalization of consumer demand in the international market, coupled with the rapid development of the internet, the many advantages of cross-border e-commerce as an emerging trading model have become more apparent. When the hybrid system synergy model is based on the effective combination of the systems, the overall performance is greater than the sum of various elements’ simple superposition. As the upstream chain of modern logistics, cross-border e-commerce requires its virtual characteristics to develop in the direction of informationization, automation, and intelligence. Only when they are interdependent and mutually promoted can they achieve greater synergy. The regional difference measurement theory is often used to measure the effect of cross-border e-commerce industry transfer. First, build a cross-border e-commerce industry transfer effect measurement model to analyze the development level of China’s cross-border e-commerce, for example, the measurement model of commercial industry transfer effects from 2001 to 2016. It is mainly because the development of modern logistics lags behind cross-border e-commerce, resulting in the inability of cross-border e-commerce and modern logistics to form an orderly coupling in the system structure and function. Therefore, to better promote the coordinated development of cross-border e-commerce and modern logistics, it is necessary to stimulate the functions of various subsystems and promote the synergy and deep integration of multiparty entities such as government, enterprises, and industry associations.

In order to study the special production, distribution, transportation, and sales of short-lived and short-lived multimedia products, this paper studies the cost and benefit optimization of a three-level supply chain network consisting of a supplier-producer-distribution center. Simultaneously, to effectively describe the actual inventory level of the retailer’s multimedia products, this paper introduces a new nonlinear function to define the real-time inventory of multimedia products to establish a biobjective nonlinear mixed-integer programming model to estimate the inventory. The research results show that the model established in this paper can not only provide the overall cost and optimal decision-making plan for the short-lived dairy supply chain but also the design method is better than the standard constraint method. Relevant research results have important potential guiding significance for research and design of supply chain network structure, measurement of multimedia product inventory levels, and improvement of customer satisfaction. The optimized design of the logistics supply chain of multimedia products with short life cycle under the background of new retail is beneficial.

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