ABSTRACT:Background:Serotonin (5-HT) is a neurotransmitter synthesized in both the central nervous system (CNS) and in enterochromaffin cells of the gut. 5-HT biosynthesis is separate between the periphery and the CNS. Any observed correlations between centrally and peripherally measured 5-HT remain to be elucidated. Previous efforts have looked for a noninvasive marker of central serotonin, including serotonin in whole blood, plasma, platelets, saliva, and urine; however, results are conflicting.Aim:Finding a noninvasive marker for central serotonin turnover that can be used for diagnosis and therapeutic monitoring in patients with primary neurotransmitter deficiencies.Methods:Inclusion criterion was all children presenting with neurological symptoms whose clinical investigations included lumbar puncture (LP) for cerebrospinal fluid (CSF) collection and neurotransmitter metabolite analysis, were recruited. For central serotonin turnover, the serotonin metabolite 5-hydroxyindoleacetic acid (5HIAA) was used. Bivariate correlation between the serotonin levels in CSF (5HIAA), platelets, and saliva was calculated.Results:Twenty-six patients (aged 6 months to 15 years) with various neurologic presentations had LP for CSF collection and neurotransmitter metabolite analysis as part of their clinical care. An additional salivary and blood sample was obtained at the same time. Eighteen patients had suitable samples for quantitative measure of serotonin. There was no correlation between platelet serotonin and CSF 5HIAA levels (Pearson’s coefficient of correlation – PCC: 0.010) or between salivary serotonin and CSF 5HIAA (PCC: 0.258). There was a strong negative correlation between salivary and platelet serotonin (PCC: −0.679).Conclusion:Our findings suggest that salivary serotonin measurement is not a suitable noninvasive marker for measuring central serotonin turnover.
The health visitors were satisfied with the theoretical instruction within the pilot program. The professionally well prepared health visitors may contribute to the success of the cervical cancer screening program. Orv. Hetil, 2017, 158(12), 461-467.
Acknowledging the limitations of this retrospective chart review, we conclude that, in our cohort, in addition to patients with movement disorders, a considerable number of patients with epilepsy and epileptic encephalopathy also showed secondary neurotransmitter mono-amine abnormalities. There is no clear relation, however, between clinical phenotype and type of neurotransmitter affected. In addition, no association was identified between the type of antiseizure medications and affected neurotransmitter type. We outline the need for prospective studies to further enrich our understanding of the relation between epilepsy and neurotransmitters with a focus on improving treatments and patient outcomes.
A 3 4 7 -A 7 6 6 A619 in screening, participation rate and habits, knowledge and sources of information) among Romany women who were selected by non-random sample selection method in Zala county, Hungary in 2015 (n= 128). Data were processed by SPSS 22.0 programme, using descriptive statistical analysis, χ 2-test, ANOVA, and multivariate logistic regression (p< 0.05). Results: As a total, 4.7% of the participants had adequate knowledge on HPV, and 17.2% of them had it on cervical cancer. Education had a significant effect on the skills related to the questions (F= 14.801, p< 0.001). 20.3% of the women never participated in cervical cancer screening, but 65.7% of them regularly go to PAP smear test every three years. The better financial status (χ 2= 7.321, Cramer V= 0.268, p= 0.007) and higher education status (χ 2= 7.187, Cramer V= 0.265, p= 0.007) determine the participation in screening within the expected period. According to the logistic regression analysis, women with higher qualification (ß= 0.963, OR= 2.619 95%CI[1.086-6.316]) and participants in good financial position (ß= 0,999, OR= 2.714 96%CI[1.094-6.738]) had greater chance to take part in screening more often than three years. They mostly attend screening (85.2%), because the negative outcome may comfort them. Shame (51.6%), inconveniences during the examination (42.2%) were indicated as the reasons for absence. ConClusions: The role of health visitors are extremely important in the health promotion because health visitors have close contact with the Romany families by their work. They could reduce the fears that keep the Romany women away from the screening and improve their knowledge about the topic and willingness to participate.objeCtives: The objective of our study was to assess the awareness related to cervical cancer and HPV and explore motivation factors and participation rate on cervical cancer screening among Romany minority women. Methods: A quantitative, cross-sectional study was conducted using self-administered questionnaire (sociodemographic data, knowledge of cervical cancer and HPV, motivation to take part
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