Coagulation disorders should be considered in unusual post-surgical bleeding, especial in low-complicated procedures even the platelet count and coagulation tests are within normal ranges.Case presentation: Male patient receive video-assisted thoracoscopic surgery (VATS) due to pleural effusion. In his clinical course, unusual bleeding and persistent and recurrent hemothorax was occurred. Coagulation Factor V disorder and resistance of the activated protein C is diagnosed. Further surgeries and blood product transfusions, tranexamic acid to control the bleeding were required. The final clinical outcome was satisfactory.
Conclusion:Coagulation Factor V deficiency is an uncommon cause of postoperative bleeding and should be considered for in all patients with abnormal bleeding.
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