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HAQ-DI scores can be used to estimate HUI-3 and EQ-5D utility values for patients with RA in data obtained from studies where utility values have not been collected.

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Rats with chemical diabetes were submitted to repeated restraint in order to investigate the diabetogenic potentiality of stress. Material and MethodUnfasted, adult Sprague-Dawley rats of about 150 g initial b.w. were employed. Blood and urine glucose determinations were performed by the glucose oxidase strip method (Vargas, Bronfman and Kawada 1974). Basal glycemia for normal rats was 92 + 0.6 mg% (M + SEM of 104 determinations). The samples were taken immediately before stress (time 0), every 60 min along 240 minutes. Restraint stress was provoked by immobilization of the rats on the operating table by moans of rubber bands tied to their extremities, procedure that permits escape movements.Two series of rats, 67 with 80% pancreatectomy and 14 with 90 % pancreatectomy (80%-P~ and 90%-P~), were submitted to repeated restraint stress. The stress began 7 days and 3 months after pancreatectomy, respectively. The 80% pancreatectomy was performed following the procedure reported by Bates and Garrison (1967).A third series of 20 intact male and 25 intact female rats was used as control. Another series consisting of 5 controls and 5 80 %-P~rats was studied at mid-day by the Oral Glucose Test (200 mg/100 g, 40% glucose solution).The post-stress glycemia-glycosuria response was classified as: a) hyperglycemic response when glycemia was between 150 and 179 mg%, without glycosuria; b) diabetic response when glycemia rose over 180 mg% accompanied by glycosuria, and came back to normal values within 4 hours; c) transient diabetes when the diabetic response lasted 8 hours or more, but returned to normal levels, and d) permanent diabetes when the diabetic response was irreversible.