Highlights d The N-terminus of NuMA folds into a hook domain that binds dynein LIC directly d NuMA bears an additional ''CC1-box-like'' dynein-binding motif within its coiled-coil d Interaction with dynein is crucial for NuMA-mediated spindle assembly and placement d We suggest NuMA being the bona fide adaptor for dynein/ dynactin mitotic functions
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