Background: Premature ventricular and supraventricular complexes (PVC and PsVC) are frequent and often symptomatic. The magnesium (Mg) ion plays a role in the physiology of cell membranes and cardiac rhythm.
BackgroundVentricular and supraventricular premature complexes (PC) are frequent and usually
symptomatic. According to a previous study, magnesium pidolate (MgP)
administration to symptomatic patients can improve the PC density and
symptoms.ObjectiveTo assess the late follow-up of that clinical intervention in patients treated
with MgP or placebo.MethodsIn the first phase of the study, 90 symptomatic and consecutive patients with PC
were randomized (double-blind) to receive either MgP or placebo for 30 days.
Monthly follow-up visits were conducted for 15 months to assess symptoms and
control electrolytes. 24-hour Holter was performed twice, regardless of symptoms,
or whenever symptoms were present. In the second phase of the study, relapsing
patients, who had received MgP or placebo (crossing-over) in the first phase, were
treated with MgP according to the same protocol.ResultsOf the 45 patients initially treated with MgP, 17 (37.8%) relapsed during the
15-month follow-up, and the relapse time varied. Relapsing patients treated again
had a statistically significant reduction in the PC density of 138.25/hour (p <
0.001). The crossing-over patients reduced it by 247/hour (p < 0.001). Patients
who did not relapse, had a low PC frequency (3 PC/hour). Retreated patients had a
76.5% improvement in symptom, and crossing-over patients, 71.4%.ConclusionSome patients on MgP had relapse of symptoms and PC, indicating that MgP is
neither a definitive nor a curative treatment for late follow-up. However,
improvement in the PC frequency and symptoms was observed in the second phase of
treatment, similar to the response in the first phase of treatment.
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