There has been a significant increase in the use of mushrooms for therapeutic and medicinal purposes, in particular, use of the species Agaricus blazei Murrill, a basidiomycota of Brazilian origin. The objective of this study was to identify scientific evidence regarding the influence of A. blazei Murrill on the immune system. We undertook an integrative review of indexed publications published between 2000 and 2009, using the following question as a guideline: "What evidence can be found in the literature regarding the influence of A. blazei Murrill on the immune system?" Fourteen studies verified that there is in vitro and in vivo research demonstrating this mushroom's influence on the immune system. All research was characterized as evidence level 7 (preclinical study [animals/in vitro]). The research shows that A. blazei Murrill functions through bioactive compounds via mechanisms that are not yet entirely clear, although it has been shown that they promote action on the innate and adaptive immunological response, activation of the complement system, and synthesis of pro- and anti-inflammatory cytokines and even aid in diapedesis. Despite broad scientific evidence demonstrating relevant immunomodulatory properties of A. blazei Murrill, randomized clinical trials with human subjects are still needed in order for the mushroom to be put into clinical practice.
There is scientific evidence to suggest that the medicinal mushroom Agaricus blazei Murrill (AbM) has immunomodulatory effects on cytokine synthesis, both in vitro and in vivo. This study was the first randomized, double‐blind, placebo‐controlled trial designed to investigate these purported actions in elderly women. The objective of this study was to ascertain the effects of AbM intake on serum levels of interleukin‐6 (IL‐6), interferon‐gamma (IFN‐γ) and tumour necrosis factor‐alpha (TNF‐α) in community‐living seniors. The sample consisted of 57 elderly females who were carriers or homozygous for the majority allele of functional polymorphisms for the chosen cytokines. Subjects were randomly allocated to receive placebo (n = 29) or AbM dry extract (n = 28), 900 mg/day for 60 days. Body mass index, abdominal girth, body composition, blood pressure and cytokine (IL‐6, IFN‐γ, and TNF‐α) levels were measured, and food intake was assessed as a possible confounder. Analysis of these parameters showed the sample was characterized by overweight and excess adiposity. After the study period, no changes from baseline were detectable for any parameter in either group. In this study, AbM extract had no modulating effect on IL‐6, IFN‐γ or TNF‐α levels in elderly females.
A dizer adeus às pessoas que amo, sem tirá-las do coração; Sorrir às pessoas que não gostam de mim, Para mostrá-las que sou diferente do que elas pensam; Fazer de conta que tudo está bem quando isso não é verdade, Para que eu possa acreditar que tudo vai mudar; Calar me para ouvir; aprender com meus erros. Afinal, eu posso sempre ser melhor. A lutar contra as injustiças, sorrir quando o que mais desejo é gritar todas as minhas dores para o mundo. A não temer o futuro; Ensinou me e está me ensinando a aproveitar o presente, Como um presente que da vida recebi, e usá-lo como um diamante que eu mesmo tenha que lapidar, lhe dando forma da maneira que eu escolher." Charles Chaplin AGRADECIMENTOS Agradeço a Deus por estar sempre ao meu lado em todos os momentos, mas principalmente na angústia e cansaço, levando-me a compreender e perceber que tenho capacidade para dar continuidade, prosseguir no caminho. Este é um momento que concilia o início e o término de mais uma etapa da minha vida, rogo a Ti, Ó Pai, que continue a iluminar o meu caminho e que me conceda a sabedoria e o discernimento... A minha família que se mostrou disposta a me auxiliar nas minhas dificuldades.Aos meus irmãos Washington, Teresa e Wanslei que consecutivamente se mostraram compreensivos nos momentos que julgava ser os mais difíceis. Amados, que vibram cada momento de conquista da nossa história.A professora Dra. Margô Gomes de Oliveira Karnikowski, o meu carinho e a minha gratidão, pois soube além de transmitir seus conhecimentos e sua experiência, me apoiou em todas as minhas dificuldades e limitações, mas que principalmente me ensinou com exemplos antes de ensinar com palavras.
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