the present results suggest that changes in fetal venous blood flow, mainly DV and LPV are useful in the management of cases with early onset placental insufficiency and that venous Doppler parameters correlate with pH at birth.

Between 1998-2002, 16,952 new cases of cancer were registered in Navarre. In men, the most frequently diagnosed cancers were in the following order: prostate, lung, colon and rectum, bladder and stomach, which accounted for 63.2%. In women, the sites were breast, colon and rectum, corpus uteri, stomach and ovary, which accounted for 57.6% of the cases. In the same period, 1998-2002, 4,127 men and 2,470 women died from cancer. Sixty percent of all deaths due to malign tumours in men were due to cancer of the lung, prostate, colon and rectum, stomach and bladder. In women this was due to cancers of colon and rectum, breast, stomach, pancreas and lung, which accounted for 49% of the cases. In men in Navarre there has been an increase in the incidence rates of cancer of the prostate, kidney and non-Hodgkin lymphoma. Avoidable cancers such as those related to smoking (lung, oral cavity and pharynx or pancreas) continue to rise, and represent a greater global risk of dying from cancer in the latest period studied than in the decades of the 1970s and 1980s. From 1995 up to the present, mortality due to cancer has moved from occupying the second place to become the first cause of death among men in Navarre. The global risk of death due to cancer in men is now equal to the first period studied, 1975-1977. Amongst women the global risk of death due to cancer fell by 25% between 1975 and 2002, basically at the cost of breast and stomach cancer. Tumours related to smoking increased both in mortality and in incidence and appear as a significant health problem amongst women in Navarre. Breast cancer has increased in incidence, with lower mortality figures than those of the first period 1975-1977. Invasive cancer of the cervix remains at very low rates in comparison with many European countries, including Spain. In both sexes colorectal and skin cancer has increased, while the incidence and mortality of stomach cancer continues to fall.

The severity of maternal asthma does not appear to have any direct influence on perinatal outcomes, and does not compromise fetal well-being. Active conduct to enable a better maternal clinical condition provides a favorable prognosis for pregnancy complicated by asthma.

Computerized cardiotocography demonstrates no association between the abnormal parameters of FHR and maternal asthma in term pregnancies. Maternal asthma was associated with less fetal movements per hour, suggesting further studies on the counting of fetal movements in pregnant women with asthma.

Objectives:The aim of this study was to determine the relation between fetal venous Doppler and acidemia at birth in pregnancies complicated by placental dysfunction before 34 weeks gestation. Methods: This was a prospective cohort study of 55 pregnancies with the diagnosis of placental dysfunction between 26 and 34 weeks of gestation. Inclusion criteria were singleton pregnancies, abnormal umbilical artery (UA) Doppler, intact membranes and absence of fetal congenital or chromosomal abnormalities. The following Doppler measurements were studied: UA pulsatility index (PI), ductus venosus (DV) pulsatility index for veins (PIV), intra-abdominal umbilical vein (UV) and left portal vein (LPV) time-averaged maximum velocity (TAMxV). Doppler exams were performed every 1 to 3 days. The last evaluation performed before delivery was analyzed. Acidemia at birth was defined as an umbilical artery pH below 7.20. Statistical analysis included Mann-Whitney-U test and the level of significance was set at P < 0.05. Results: Twenty-six newborns (48.1%) had acidemia at birth. Acidemic fetuses presented significantly lower UV-TAMx velocity than fetuses with normal pH at birth (0.81 ± 0.51 mL/min vs. 1.09 ± 0.54 mL/min, P = 0.04). The UA-PI was significantly increased in acidemic fetuses when compared with fetuses with normal pH at birth (2.93 ± 1.66 vs. 2.03 ± 0.96, P = 0.02). No difference was found in the analysis of other vessels. Conclusions: Placental dysfunction before 34 weeks of gestation is associated with low velocity flow in the intra-abdominal umbilical vein, that may be due to decreased cardiac function. Consideration of the clinical context and other cardiac and arterial Doppler parameters is important in distinguishing the pathophysiology of fetal response to hypoxia. P12.07Fetal heart preload assessment in course of tocolytic fenoterol treatment in preterm labour Objectives: The preload index (PLI) has been shown to increase in the presence of uterine contractions. It was our aim to determine whether any changes in PLI are observed in the course of fenoterol intravenous tocolytic treatment of normal fetuses. Methods: Doppler measurements were obtained for inferior vena cava (IVC) of 23 normal fetuses at 24-34 weeks of gestation in the presence of uterine contractions as a symptom of preterm labour. A and S values were measured from the recorded blood flow velocity waveform of IVC to calculate the A/S ratio described as preload index. These measurements were calculated at the moment of patients' admittance to the hospital as well as after 24 and 48 hours of fenoterol tocolytic treatment. All qualified patients were treated successfully and none of them delivered before 37 weeks of gestation. Results: Analysis of variance (ANOVA) in repeated measurement model has not shown a significant change over time in PLI before and after 24 and 48 hours of fenoterol tocolytic treatment. This observation was consistent with ANOVA post-hoc analysis. Conclusions: Increased fetal PLI values remained unchanged despite fenoterol trea...

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