In this study, PCL electrospun fibers were deposited on the Ti-30Ta alloy for change the surface properties. Experimental Ti-30Ta alloy was obtained by melting titanium and tantalum in arc melting furnace with argon atmosphere. Ingots were homogenized and bars with 10 mm of diameter were obtained in rotative swagging. PCL fibers were deposited on disks of the alloy by electrospinning. Plasma treatment was carried out for change PCL electrospun superficial energy by using stainless steel plasma reactor. Samples were immersed in mineralization solution for apatite growth. Surfaces were evaluated by using SEM, X-rays diffraction and contact angle. Samples exhibited hydrophilic behavior after plasma treatment and mineralization. Results are very interesting for biomedical applications.
A large clot formed between the inside of the bony wall of the extraction socket and the immediate implant surface may have premature breakdown . Tranexamic acid (TXA) is fibrinolysis inhibitor and an analog of the amino acid lysine. In this paper the influence of tranexamic acid on the osseointegration of Ti-30Ta implants without primary stability was investigated. Were fabricated 32 implants of CP Titanium Grade 4 and 32 implants of Ti-30Ta alloy with dimensions of 2.1 x 2.8mm Ø. Bone defects of 2.5x3.2 mm Ø were created in right tibia of 64 Wistar male-rats using a small round bur. They were divided (n=16) into: Group I (CP-Ti machined implant), Group II (CP-Ti machined implant/ tranexamic acid), Group III (Ti-30Ta implant) and Group IV (Ti-30Ta implant/ tranexamic acid). The surgical defects of the Group II and Group IV were bathed with 20 ml of the tranexamic acid solution. The animals were euthanized at 45 days postoperative. In the right tibia of half each group (8 animals/8 tibiae) the maximum torque value necessary for manual removal of each implant was measured in Newton centimeters (Ncm). The right tibia of other half each group was subjected to non-decalcified histology processing (Stevenel's blue/Alizarin red). Data were analyzed statistically (Kruskal-Wallis Analyses) and demonstrated significant differences (P<0.05) among groups. The values of group I were significantly lower than group III and IV, but without significant difference than group II both removal torque and peri-implant bone healing. The results suggest that: a) peri-implant bone formation occurred more rapidly around the Ti-30Ta implant; b) tranexamic acid favored the stabilization of blood clot and bone formation around Ti-30Ta implants and not influenced bone formation around Ti-CP implants.
The manufacturing processes of polymeric implants for controlled drug release suggest a promising perspective of use for chemotherapeutic treatments. The objective of this study was to carry out a bibliographical survey of the last 10 years with experimental works to draw up a profile of methodologies and results achieved in this area. The literature search revealed 739 references, of which 19 were selected. The manufacturing by extrusion and injection are the most used. Regarding geographical distribution, Brazil occupies the 2nd place in the general list. The analysis of the literature on controlled release techniques of chemotherapeutic drugs demonstrates the scarce production in this area. It would be of great interest to have more studies on this topic, since it would be an alternative in the chemotherapeutic treatment.
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