Androgenetic alopecia (AGA) is the most diagnosed hair loss dysfunction. Its physiopathology comprises a genetic predisposition affording an exacerbated response of the hair follicles cells to androgens aggravated by scalp inflammation and extrinsic factors. This paper presents a review of the mechanisms and extrinsic factors involved in the AGA physiopathology as well as its conventional and emerging treatments. The research focused on reports regarding AGA physiopathology and treatments published between January 2001 and July 2019 in medical and related journals. The most used medical treatments for AGA—minoxidil and finasteride—present non satisfactory results in some cases. Currently, the low‐level laser therapy is recognized as a safe and effective treatment for AGA. Some minimally invasive techniques—mesotherapy, microneedling, carboxytherapy, and platelet‐rich plasma—are also used to stimulate hair growth. Pharmaceutical substances with mechanisms differing from the anti‐androgen activity are under current investigation and many of them have botanical origins; however, formulations with higher performance are required, and the hair follicles ability of being a drug and nanoparticle reservoir has been researched. The association of different strategies, that is, substances with synergic mechanisms and the use of advantageous technologies associated with lifestyle changes could improve the treatment outcomes.
This paper analyzes and describes a fi rst occurrence of the conodonts Ellisonia, Gondolella and Ubinates in Amazonas Basin, North of Brazil. The recovered material comes from two outcrops along the Tapajos River and from a limestone quarry of Itaituba Formation, whose levels are included in the Itaituba Formation, with a Pennsylvanian age. Those conodonts are relevant paleoecological indicators of water depth, salinity and environmental energy and have implications in the Late Carboniferous to Triassic biostratigraphy. The fossil remains represent M and S conodont elements, associated to Pa elements of the Idiognathodus, Idiognathoides, Neognathodus, Adetognathus, Hindeodus and Diplognathodus genus.
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