The objective of this research was to obtain a dual coating with antimicrobial properties on TiZr implants. The metallic surfaces were modified with two biopolymers (poly(lactic acid) and polycaprolactone), the first deposited by dip coating and the second by electrospinning, in order to create a nanofibers type of coating with antibacterial and bioactive effect. The surface characteristics of the obtained bioactive coatings were evaluated by Fourier Transformed Infrared Spectroscopy, by scanning electron microscopy and by contact angle measurements. The electrochemical characterization of the coatings was performed in simulated body fluid. The metallic ion release from the coated implant materials was measured by inductively coupled plasma mass spectrometry. The in vitro antimicrobial properties of the coatings were studied using agar disc diffusion method and percentage inhibition of growth method for two bacterial strains—S. aureus and E. coli. The presence of silver nanoparticles presented high inhibition zone against gram negative bacteria like E. coli. Cell viability of MC3T3-E1 osteoblasts and cytoskeleton morphology, were tested in vitro for the biological evaluation. The results on in vitro cell response indicated good cell membrane integrity and viability for such nanofibrous bioactive coatings compared to the control substrate. These surface architectures design on implant materials holds promise for biomedical applications, presenting good antimicrobial properties and promote cell adhesion and proliferation.
Metallic implants are widely used in the field of implantology, but there are still problems leading to implant failures due to weak osseointegration, low mechanical strength for the implant, inadequate antibacterial properties, and low patient satisfaction. Implant failure can be caused by bacterial infections and poor osteointegration. To improve the implant functionalization, many researchers focus on surface modifications to prepare the proper physical and chemical conditions able to increase biocompatibility and osteointegration between implant and bone. Improving the antibacterial performance is also a key factor to avoid the inflammation in the human body. This paper is a brief review for the types of coatings used to increase osseointegration and biocompatibility for the successful use of metal alloys in the field of implantology.
The objective of the present study is the valorization of natural resources and the recycling of vegetal wastes by converting them into novel plasmonic bio-active hybrids. Thus, a “green” approach was used to design pectin-coated bio-nanosilver. Silver nanoparticles were generated from two common garden herbs (Mentha piperita and Amaranthus retroflexus), and pectin was extracted from lemon peels. The samples were characterized by the following methods: Ultraviolet–visible (UV-Vis) absorption spectroscopy, Fourier Transform Infrared (FT-IR), X-ray Diffraction (XRD), X-ray Photoelectron Spectroscopy (XPS), dynamic light scattering (DLS), Atomic Force Microscopy (AFM), Scanning Electron Microscopy (SEM)–Energy-dispersive X-ray Spectroscopy (EDX), and zeta potential measurements. Microscopic investigations revealed the spherical shape and the nano-scale size of the prepared biohybrids. Their bioperformances were checked in terms of antioxidant and antibacterial activity. The developed plasmonic materials exhibited a strong ability to scavenge short-life (96.1% ÷ 98.7%) and long-life (39.1% ÷ 91%) free radicals. Microbiological analyses demonstrated an impressive antibacterial effectiveness of pectin-based hybrids against Escherichia coli. The results are promising, and the obtained biomaterials could be used in many bio-applications, especially as antioxidant and antimicrobial biocoatings.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.