SFC may be used to delay the use of ADT. Further assessment of our findings with high-powered studies and longer follow-up is required.

Purpose. Active surveillance is an emergent strategy for management of indolent prostate cancer. Our institution's watchful waiting protocol, Active Holistic Surveillance (AHS), implements close monitoring for disease progression along with various chemopreventive agents and attempts to reduce unnecessary biopsies. Our objective is to report on the treatment rates of men on our AHS protocol as well as determine reasons for progression. Materials/Methods. Low risk and low-intermediate risk patients were enrolled in AHS at Winthrop University Hospital between February 2002 and August 2015. Our IRB-approved study analyzed survival rate, discontinuation rates, and definitive treatments for patients in our AHS cohort. Results. 235 patients met inclusion criteria. Median age and follow-up for the cohort were 66 (44–88) years and 42 (3–166) months, respectively. The overall survival for the cohort was 99.6% and the disease specific survival was 100%. A total of 27 (11.5%) patients discontinued AHS. Conclusion. The incorporation of chemopreventive agents in our AHS protocol has allowed patients to prolong definitive treatment for many years. Longer follow-up and additional studies are necessary to further validate the effectiveness of AHS.

Organic ultraviolet filter chemicals (UVFCs) are the active ingredients used in many sunscreens to protect the skin from UV light; these chemicals have been detected in numerous aquatic environments leading to concerns about how they might affect aquatic organisms and humans. One commonly used organic UVFC is octyl methoxycinnamate (OMC), better known by its commercial name, octinoxate. Upon exposure to UV light, OMC degrades rapidly, forming numerous photoproducts, some of which have been previously identified. In this study, we isolated and completely characterized the major products of OMC photolysis, including the two major stable OMC cyclodimers. One of these cyclodimers is a δ-truxinate, resulting from a head-to-head dimerization of two OMC molecules, and the other cyclodimer is an α-truxillate, resulting from a head-to-tail dimerization of two OMC molecules. Additionally, the cellular toxicities of the individual photoproducts were determined; it was found that the parent UVFC, OMC, 4-methoxybenzaldehyde, and two cyclodimers are significantly toxic to cells. The photoproduct 2-ethylhexanol is not cytotoxic, demonstrating that different components of OMC photolysate contribute differently to its cellular toxicity. This study thus provides an enhanced understanding of OMC photolysis and gives toxicity data that can be used to better evaluate OMC as a sunscreen agent.

26 Background: The salvage therapy options for patients with recurrent unilateral prostate cancer after primary radiation, or cryotherapy, are limited. Salvage focal cryotherapy is becoming a more popular treatment option as it has shown success in its disease-free survival rates. Salvage focal cryotherapy enables patients to delay or negate the use of hormone therapy, which has many unfavorable adverse effects. The aim of this study is to report on the curative success of salvage focal cryotherapy in patients with recurrent unilateral prostate cancer. Methods: We identified patients who underwent salvage focal cryotherapy at Winthrop University Hospital between February 2011 and August 2015. Age at the time of treatment, follow-up time, nadir PSA levels, and follow-up treatments were assessed. Results: From 2011 to 2015, 88 patients underwent salvage focal cryoablation. Of these patients, 14 (15.9%) required another therapy treatment after salvage focal cryoablation. Hormone therapy was a necessary treatment for 9 patients. Only 6 patients (6.8%) went on to hormone therapy due to an MRI finding of a local, nodal, or distant relapses. Three (3.4%) patients went on to hormone therapy due to a rise in PSA. Conclusions: Focal salvage therapy is associated with very low risk of clinical and radiographic progression of cancer. In our patients with radiation recurrent cancer, we were able to prevent or delay the use of hormone therapy in the majority of these men. [Table: see text]

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WithoutRace, respectively). Distribution of patients and changes within CKD stages with different equations was considered. Subgroup analysis was completed on patients with stage III-IV disease only.RESULTS: 459 self-identified black patients that underwent nephrectomy at our institution were identified, 135 of which had stage III-IV disease. eGFR decreased around 10-13ml/min/1.73m2 with removal of the race coefficient. 13-22%, 6-12%, and 2-3% more black patients would fall under common CKD cutoffs of 60, 45, or 30ml/min/1.73m2, respectively, depending on the equation used (Figure 1). Subanalysis of stage III-IV patients only were similar.CONCLUSIONS: Race free renal function equations may result in significantly more black patients being encouraged to undergo nephron sparing treatments.Source of Funding: We gratefully acknowledge the support of the John Robinson Family Foundation and the Chris Churchill Family Foundation

METHODS: We extracted data on men with a tissue diagnosis of prostate cancer between January 2017 and December 2019 from the Victorian Prostate Cancer Outcomes Registry (PCOR-Vic). We evaluated trends and comparisons between patients receiving PET/CT (with or without conventional imaging (CImg)), and CImg alone, and analysed imaging modality as predictor of clinical regional node positive disease (cN1 vs cN0/X), metastatic disease (cM1 vs cM0/X), and treatment received.RESULTS: In total, 10288 patients in the registry had either a staging PET scan (n [ 1599, 16%), CImg without PET scan (n [ 3539, 34%), or no recorded PET or CImg (n [ 5150, 50%). The proportion of all imaged patients who received staging PET increased from 21% to 39% from the first to last six-month period, and in the patients with grade group !3, the increase was 23-43%. After adjustment for grade group, PET vs CImg-only patients were observed to have a higher proportion of cN1 disease (OR [ 2.48, 95% CI: 2.04-3.03) but not cM1 disease (OR [ 1.06, 95% CI: 0.87-1.29).CONCLUSIONS: Our registry data highlights the rapid uptake of PET imaging, particularly in higher grade disease. Based on this data, we underline the increased diagnosis of nodal disease, thus potentially optimizing patient selection prior to definitive treatment for prostate cancer.

total of 179 complications were recorded mainly during the early follow-up period. There were 157 Clavien-Dindo grade 1-2 and 22 grade 3 complications. There were no grade 4 or 5 complications CONCLUSIONS: Cryoablation is a viable minimally invasive salvage management option for rr-PCa. Durable DFS with acceptable morbidity can be achieved. sCRYO should be considered as a treatment options for appropriately selected patients deemed suitable for local salvage therapy.