A free radical multicomponent reaction mediated by an acidic TiCl(4)-Zn/H(2)O(2) system allows the assembly of an amine, a ketone, and formamide in one pot, affording instant access to quaternary alpha-amino acid derivatives.
The reaction provides a fast, mild, and chemoselective method for the reductive pinacolization of aromatic aldehydes to give the corresponding 1,2-diols as 1:1 mixtures of diastereomers. The active reducing agent is found to be the α-hydroxyalkyl radical generated from the alcoholic cosolvent iPrOH or EtOH by reaction with the tBuO radical. -(CLERICI, A.; GRECO, C.; PANZERI, W.; PASTORI, N.; PUNTA, C.; PORTA*, O.; Eur.
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