Purpose This is a collaborative case-control study from Ophthalmology and Cardiology departments of a tertiary care hospital, designed to explore the relationship between coronary artery disease (CAD) and pseudoexfoliation syndrome (PEX). Method In all, 50 patients with CAD proven by coronary angiography, and 50 controls with normal coronary angiographic findings were compared in terms of PEX, other vascular diseases, and retinal vascular findings. v 2 -test and Student's t-test were used for statistical analysis. Results The number of patients with PEX among CAD ( þ ) patients was substantially larger than controls. In all, 28 of 50 CAD ( þ ) patients and only 12 of 50 CAD (À) patients had PEX. PEX was significantly associated with CAD (P ¼ 0.001). When all patients were regrouped according to the presence of PEX, patients with PEX did not differ from patients without PEX in terms of age (P ¼ 0.360) and sex (P ¼ 0.507), but the prevalence of CAD was higher (P ¼ 0.001) and fundoscopic findings of vascular diseases were significantly more prominent (P ¼ 0.0001) in PEX ( þ ) patients. Discussion We demonstrated statistically significant difference in the prevalence of PEX in CAD patients, and also in the prevalence of CAD in PEX ( þ ) individuals. These were striking differences. We should consider the possibility of the presence of PEX in CAD patients; and the predisposition of PEX ( þ ) persons for CAD, which necessitates a fundus examination for findings of systemic vascular diseases.

The results demonstrated the efficacy of tissue glue for closing site ports when wound leakage is observed in transconjunctival sutureless vitreoretinal surgery.

Ocular bioavailability of ofloxacin in aqueous humor after oral and topical administration is similar when the drug is applied as described. Penetration of ofloxacin into vitreous humor is less than that into aqueous humor following topical application. The aqueous humor levels of ofloxacin via both routes and the vitreous level of the drug after oral route exceed the minimum inhibitory concentrations for certain bacterial species that frequently cause intraocular infection.

* BACKGROUND AND OBJECTIVE: To der ermine whether the diameter of the capsulorhexis has an effect on anterior chamber depth (ACD) following phacoemulsification surgery. * PATIENTS AND METHODS: Fifty-one consecutive patients were selected for cataract extraction by phacoemulsification with intraocular lens (IOL) implantation. Twenty-two of 5 1 patients underwent 4 mm capsulorhexis, while the rest underwent 6 mm. All were implanted with a multi-piece polymethyl methacrylate posterior chamber IOL with 5.0 mm diameter biconvex optic and flexible haptic. They were followed 3 months postoperatively. The width of the capsulorhexis was assured according to the IOL optic implanted intraoperatively, and by the help of slitlamp measurement after dilatation of the pupil on the first postoperative day. ACD and axial length (AL) of patients was obtained by ultrasonography on both the days before surgery, and the first and seventh postoperative days, and after 30, 60 and 90 days. * RESULTS: Early significant increase of ACD and ACD/AL ratios were observed in only the 6 mm capsulorhexis group on the first day postoperatively (P = .012, and P= .018). On the 90th postoperative day, ACD increased significantly both in the 4 mm (P = .002) and the 6 mm capsulorhexis groups (P = .049) when compared to preoperative values. For the same period, meaningful increase in ACD/AL ratio in the eyes with both 4 mm and 6 mm capsulorhexis groups was also noted compared with preoperatively (P= .002 and P = .019). There was a statistical difference between the 90th day ACD values of 4 mm (3.73 ± 0.32 mm, mean ± standard deviation) and 6 mm capsulorhexis groups (3.50 ±0.33 mm) (P= .028). For the same period, ACD/AL ratio was also significantly different for both groups (0.152 ±0.01, and 0.142 ±0.01 respectively) (P = .004). The refractive error changes followed the ACD changes and showed meaningful differences between 1st and 90th days postoperative values of each group (P= .029» and P= . 014, respectively). * CONCLUSION: A 4 mm capsulorhexis results in a longer postoperative ACD than does a 6 mm capsulorhexis for the IOL type used in this study. [Ophthalmic Surg Lasers 1999;30:185-190.]

Ocular bioavailability of ciprofloxacin in aqueous humour following oral and topical administration is found to be similar when the drug was applied as described above. Penetration of ciprofloxacin into vitreous humour is less than that into aqueous humour after topical administration.