Acyl hydrazides constitute very important moieties in organic chemistry and have been employed as starting materials for different transformations to many classes of organic compounds. In this review, at first the approaches towards the synthesis of acyl hydrazides are presented. Furthermore, in the second part, the uses of this skeleton as an important intermediate for the synthesis of useful organic compounds are analyzed.1 Introduction2 Approaches towards the Synthesis of Acyl Hydrazides2.1 Synthesis of Acyl Hydrazides from Aldehydes2.2 Synthesis of Acyl Hydrazides from Carboxylic Acid Derivatives3 Acyl Hydrazides as Useful Synthons in Synthetic Organic Transfor mations3.1 Acyl Hydrazides as Synthetic Precursors for the Synthesis of Car bonyl Compounds3.2 Acyl Hydrazides as Synthetic Precursors for the Synthesis of Het erocyclic Rings4 Conclusion
The phenol moiety appears in a wide variety of natural products, exhibiting biological activity, and in numerous active pharmaceutical compounds. Boronic acids are potential precursors of the phenol scaffold and a plethora of efforts has been focused in developing novel and green protocols, targeting their chemoselective transformation into phenols. Photochemistry is a rapidly expanding research field converting light energy into chemical potential. Photochemical aerobic processes possess additional advantages to photochemistry and may find applications in chemical industries. Herein, a low-catalyst loading anthraquinone-catalyzed photochemical process is demonstrated, under CFL lamp irradiation, while exploiting 2-Me-THF as the reaction medium for the conversion of boronic acids to phenols. Furthermore, a broad substrate scope was employed.
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