Antiserums produced against certain isolated human myeloma IgGglobulins and absorbed in order to show only individual antigenic specificity crossreact with certain Waldenstrom IgM-globulins. Some of the common antigenic determinants revealed by these cross-reactions depend on the tertiary and quaternary structure of the IgG and IgM molecules and are independent of their K and L light-chain antigenic types.

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A B S T R A C T Studies of a number of properties of the pathological -vA-proteins in the first four cases of the recently recognized alpha-chain disease demonstrate that, as in -v-heavy-chain disease, the abnormal protein is devoid of light chains and represents a portion of the a-heavy chain related to the Fc-fragment. In two patients, serum electrophoresis showed a broad abnormal band, whereas in the two others the pathological protein was not noticeable on the electrophoretic pattern. The diagnosis of a-chain disease can be established without purification of the protein by immunoelectrophoresis and gel diffusion experiments using selected antisera to 'vA and a reference a-chain disease protein. All four proteins belonged to the al-subclass, displayed electrophoretic heterogeneity. and showed a strong tendency to polymerize. The polymers occurred in vivo and were held together both by disulfide bonds and by strong noncovalent forces. Two of the three purified proteins had a very high carbohydrate content. The abnormal protein was always found in concentrated urines in variable but generally low amounts. It was not detected in parotid saliva but was present in significant amounts in jejunal fluid of all four patients. The a-chain disease protein was shown to be associated with the secretory piece in external secretions of two patients.The clinicopathological features were strikingly similar in the four patients. All patients were affected with a neoplastic and mostly plasmacytic proliferation involving primarily the whole length of the small intestine and the mesenteric nodes and all exhibited a severe malabsorption syndrome. While Israeli authors have emphasized the frequency of this type of abdominal lymphoma in young Arabs and non-Ashkenazi Jews, two of our patients were Kabyles, one a Syrian Arab, and one an Eurasian. Cellular studies showed that the pathological Dr. Rambaud's present address is

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