Sham-feeding studies using liquid diets and mildly food-deprived rats suggest the existence of two types of control signals that determine liquid meal size. One appears to be a signal arising from activation of tension receptors in the stomach wall that set an upper limit on the size of a meal. The other appears to be a signal that controls the rate at which fluid is ingested. This second type of signal may be a form of conditioned control of ingestion because repeated experience with sham feeding leads to progressive increases in the drinking rate. The progressive increase may reflect the extinction of a control signal that normally modulates the rate of fluid ingestion.
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