Objectives
In the Fluid and Catheter Treatment Trial (FACTT) of the National
Institutes of Health Acute Respiratory Distress Syndrome Network, a
conservative fluid protocol (FACTT Conservative) resulted in a lower
cumulative fluid balance and better outcomes than a liberal fluid protocol
(FACTT Liberal). Subsequent Acute Respiratory Distress Syndrome Network
studies used a simplified conservative fluid protocol (FACTT Lite). The
objective of this study was to compare the performance of FACTT Lite, FACTT
Conservative, and FACTT Liberal protocols.
Design
Retrospective comparison of FACTT Lite, FACTT Conservative, and FACTT
Liberal. Primary outcome was cumulative fluid balance over 7 days. Secondary
outcomes were 60-day adjusted mortality and ventilator-free days through day
28. Safety outcomes were prevalence of acute kidney injury and new
shock.
Setting
ICUs of Acute Respiratory Distress Syndrome Network participating
hospitals.
Patients
Five hundred three subjects managed with FACTT Conservative, 497
subjects managed with FACTT Liberal, and 1,124 subjects managed with FACTT
Lite.
Interventions
Fluid management by protocol.
Measurements and Main Results
Cumulative fluid balance was 1,918 ± 323 mL in FACTT Lite,
−136 ±491 mL in FACTT Conservative, and 6,992 ± 502
mL in FACTT Liberal (p < 0.001). Mortality was not
different between groups (24% in FACTT Lite, 25% in FACTT
Conservative and Liberal, p = 0.84).
Ventilator-free days in FACTT Lite (14.9 ±0.3) were equivalent to
FACTT Conservative (14.6±0.5) (p = 0.61)
and greater than in FACTT Liberal (12.1 ±0.5, p
< 0.001 vs Lite). Acute kidney injury prevalence was 58% in
FACTT Lite and 57% in FACTT Conservative (p
= 0.72). Prevalence of new shock in FACTT Lite (9%) was
lower than in FACTT Conservative (13%) (p =
0.007 vs Lite) and similar to FACTT Liberal (11%)
(p = 0.18 vs Lite).
Conclusions
FACTT Lite had a greater cumulative fluid balance than FACTT
Conservative but had equivalent clinical and safety outcomes. FACTT Lite is
an alternative to FACTT Conservative for fluid management in Acute
Respiratory Distress Syndrome.
The fields of pediatric gastrointestinal endoscopy and sedation are critically important to the diagnosis and treatment of gastrointestinal (GI) disease in children. Since its inception in the 1970s, pediatric endoscopy has benefitted from tremendous technological innovation related to the design of the endoscope and its associated equipment. Not only that, but expertise among pediatric gastroenterologists has moved the field forward to include a full complement of diagnostic and therapeutic endoscopic procedures in children. In this review, we discuss the remarkable history of pediatric endoscopy and highlight current limitations and future advances in the practice and technology of pediatric endoscopy and sedation.
Millions of concussions occur every year in the United States. The public interest in concussion has increased after a number of high-profile deaths in high school athletes from sports-related head trauma and in some professional athletes from chronic traumatic encephalopathy. One of the most active areas of research in sports medicine during the last decade has been the evaluation and management of concussion. In this second article of a two-part series, we provide an overview of the latest scientific advances in concussion research. This overview includes an update on the pathobiological changes that occur during concussion and the results of biomechanical studies. In addition, to aid the practicing clinician, we review the literature on proven and currently studied concussion risk factors, including a history of concussion, fatigue, and age. Genetic polymorphisms and biomarkers may provide risk-prediction capability, but at present the research remains inconclusive. Diffusion tensor imaging and functional magnetic resonance imaging are promising technologies that reveal more sophisticated data about the impact of concussion on the brain. We review the existing literature on the application of these neuroimaging modalities to sports concussion. An update from the Fourth International Conference on Concussion in Sport, with highlights of new recommendations, and the presentation of the third edition of the Sports Concussion Assessment Tool to evaluate acute concussion, concludes our review.
Metastatic Crohn's disease (MCD) is the manifestation of Crohn's disease outside of the gastrointestinal tract and most frequently involves mucocutaneous and pulmonary tissues. This is an uncommon phenomenon but is well characterized in the pediatric literature. In contrast, MCD affecting the liver has not previously been described in pediatrics. The pediatric gastroenterologist must be aware of the myriad of Crohn's disease-associated hepatopathies. We herein present the first reported case of pediatric MCD involving the liver and describe our targeted diagnostic evaluation and the patient's response to infliximab-dyyb.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.