Docetaxel is extensively used in chemotherapy for the treatment of breast cancer. Little attention has been given to oedema as a possible side effect of docetaxel-containing therapies. Until now, no review was conducted to evaluate docetaxel-containing therapies versus docetaxel-free therapies on the magnitude of the risk of developing oedema. In this systematic review, we investigated the risk of developing oedema in patients being treated for breast cancer with or without docetaxel. In this systematic literature review, we searched PubMed and Web of Knowledge for studies on breast cancer patients treated with chemotherapy containing docetaxel. We included clinical trials comparing docetaxel versus docetaxel-free chemotherapy. Oedema had to be reported and measured as a key outcome or an adverse effect. Methodological checklists were used to assess the risk of bias within the selected studies. Seven randomised clinical trials were included. Six trials were of moderate methodological quality. All trials showed an increased rate of oedema in the docetaxel-treatment arm. The trial of weakest methodological quality reported the highest incidence of oedema. The results moderately suggest that adjuvant chemotherapy containing docetaxel is related to a significantly increased risk of developing oedema, compared with docetaxel-free chemotherapy.
Several studies support the validity and psychometric properties of the DT&PL for measuring psychosocial distress in breast cancer survivors (BCSs). However, next to psychosocial problems, it is equally important to identify distress caused by limitations in physical functioning. Validity of the DT&PL for the identification of physical problems in BCSs has not yet been investigated. Therefore, the purpose of the present study is to investigate the concurrent validity and psychometric properties of the Dutch DT&PL in BCSs for the identification of physical problems. Ninenty BCSs completed the DT&PL, ShortForm-36 (SF-36) and the Dutch Disability of the Arm, Shoulder and Hand questionnaire (DASH). Forty-seven % of BCSs reported a high level of distress on the DT&PL (score ≥5). Distressed BCS showed increased physical and emotional problems and problems at the upper limb region. The scores obtained with the DT&PL correlated weakly to strongly with subscales for physical functioning of the SF-36 (r = -0.224 to r = -0.676; p < 0.05) and with limitations in physical functioning at the upper limb region (DASH; r = 0.380 to r = 0.619; p < 0.01). In conclusion, the Dutch DT&PL is a multidimensional instrument showing good concurrent validity for the screening of physical problems.
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