A simple
tool to perform multiple reactions in parallel in batch
mode in static segments within a single tube is described. The Segmented
Tube Reactor (STR) involves using syringe pumps to load a section
of Teflon tubing with solutions of reaction components while forming
a preprogrammed gradient of one of the components (e.g., equivalents,
concentration) along its length. Simultaneously, a chemically inert
spacer is loaded to break the gradient into discrete static segments.
Ten or more distinct sets of conditions can be quickly set up in a
single experiment. Although the STR is set up in flow mode, reactions
occur in batch mode within the tubes, usually by heating the STR for
a desired duration. Segments are then individually sampled and analyzed
to identify the conditions that provide the best performance. The
technology is translatable: the STR was employed to screen for preferred
reaction stoichiometries that were then duplicated on larger scale
in batch mode in traditional lab equipment.
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