BackgroundChinese citizens regularly experience some form of bodily pain, yet little is known regarding the epidemiology of pain.MethodsWe conducted a nationally representative sample cross sectional study to estimate the prevalence of pain and identify risk factors of pain among 19,665 community residents aged 18–65 years in China. The China Sub-optimal Health Survey (CSHS) data was used to estimate pain prevalence. Body pain was also estimated by self-reports from the sample population. A logistical regression model was applied to estimate the odds ratio and 95 % CIs of acute pain and chronic pain to explore the potential risk factors.ResultsWomen had a higher prevalence of pain than men (39.92 vs. 32.17 % for chronic pain). The prevalence of pain increased with age (29.72 % for ages 18–25 vs. 42.23 % for ages 45–65). The most common complaints were head, neck/shoulder, and waist/back pain. Females (OR 1.57, 95 % CI 1.44–1.71) ages 25 or older (25–45: OR 1.19, 95 % CI 1.04–1.36; 45–65: OR 1.47, 95 % CI 1.26–1.73) were more likely to report having chronic pain. Subjects’ living areas, and their drinking status (OR 1.32, 95 % CI 1.13–1.53) or smoking status (OR 1.01, 95 % CI 0.91–1.11), were also factors that were significantly associated with increased reporting of chronic pain.ConclusionWomen had a higher prevalence of chronic pain than men, although both sexes had a high prevalence for chronic pain. There were significant differences between the two sexes and the location of chronic pain in the body, most notably in the shoulders, stomach, abdomen, and waist.

Recently, it has been shown that enzyme encapsulation inside metal–organic frameworks (MOFs) can increase enzyme activity and serve as protection from adverse environmental conditions. Little is understood about how the enzymes move into and are held inside the MOFs although it is believed that intermolecular forces between the MOF and the enzyme cause it to be held in place. If this process can be better understood, it can have dramatic implications on the cost-effectiveness and implementation of enzyme–MOF complexes. This is of specific importance in the medical sector for protein therapy and the industrial sector where enzyme use is expected to increase. Herein, we synthesized alcohol dehydrogenase (ADH) and PCN-333 to study encapsulation, stability, and enzyme activity to expand the knowledge of our field and offer a potential improvement to a synthetic route for biofuel synthesis. From this, we found a correlation between the concentration of a buffer and the loading of an enzyme, with surprising loading trends. We conclude that the buffer solution decreases interactions between the enzyme and MOF, supporting conventional theory and allowing it to penetrate deeper into the structure causing higher enzyme loading while allowing for excellent stability over time at various pH values and temperatures and after multiple reactions. We also observe new trends such as a rebounding effect in loading and “out-of-bounds” reactions.

ObjectiveThis study aims to discuss the correlation between daily reported H7N9 cases and stock price indices in China.MethodsInformation on daily reported H7N9 cases and stock market sectors indices between February 19, 2013 and March 31, 2014 were collected. A distributed lag non-linear model was used to describe the variation trend for the stock indicesResultsThe daily reported number of H7N9 cases was associated with the closing price of the Avian Influenza Sector Index (P < 0.05) and the opening price of the Shanghai Composite Index (P = 0.029). The Avian Influenza Sector Index decreased with increasing of daily reported case number when daily reported cases ≤ 4. Case number was associated with the opening/closing price of the Chinese Traditional Medicine Sector Index, the Biological Product Sector Index, and the Biomedicine Sector Index (P < 0.05).ConclusionNew or reemerging infectious diseases epidemic cause economic loss which is reflected in movements in stock prices.

Objectives: The present study aimed to investigate the knowledge of Middle East Respiratory Syndrome (MERS) among Chinese medical students. Methods: A structured questionnaire on MERS was conducted among 214 medical students in China. Results: The average correction of the single question varied from 36.0% to 89.7%. There is a significant difference on MERS knowledge among different majors of medical students (p < 0.05). Management students scored significantly higher than students of other majors (p < 0.05). Conclusion: Chinese medical students had good knowledge of MERS. The MERS knowledge score varied among students of different majors. Education on disease control should be included in the school curriculum.

Background To describe sociodemographic factors associated with head and neck cancer (HNC) survival among patients with distant metastatic disease. Methods We retrospectively analyzed national data for 2889 adult patients with metastatic HNC (2007‐2015). We used Fine and Gray competing risks proportional hazard models, stratified by oropharyngeal cancer status, controlled for sociodemographic factors (age, sex, race/ethnicity, marital status, and insurance status), and accounted for multiple testing. Results Median survival time was 11 months (15 months for patients married/partnered; 13 months for patients with non‐Medicaid insurance; P < .01). Among patients with oropharyngeal cancer, being married/partnered was associated with lower mortality hazard (sdHRdivorced/separated = 1.37, 97.5% confidence interval [CI] = 1.07, 1.75; and sdHRnever married = 1.43, 97.5% CI = 1.14, 1.80), as was having non‐Medicaid insurance (sdHRuninsured = 1.44, 97.5% CI = 1.02, 2.04). Conclusions Health insurance and marital status are sociodemographic factors associated with survival among HNC patients with distant metastatic disease, especially in oropharyngeal cases.